Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 27156..27744 Replicon chromosome
Accession NZ_CP019388
Organism Winogradskyella sp. J14-2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag BWZ20_RS00195 Protein ID WP_054560627.1
Coordinates 27442..27744 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BWZ20_RS00190 Protein ID WP_054560626.1
Coordinates 27156..27440 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ20_RS00160 23437..24144 - 708 WP_076614721.1 hypothetical protein -
BWZ20_RS00165 24188..25081 - 894 WP_157358271.1 IS3 family transposase -
BWZ20_RS00170 25039..25410 - 372 WP_042249904.1 transposase -
BWZ20_RS00175 25602..26147 - 546 WP_076614724.1 DUF5063 domain-containing protein -
BWZ20_RS00180 26303..26728 - 426 WP_076614725.1 hypothetical protein -
BWZ20_RS00190 27156..27440 - 285 WP_054560626.1 putative addiction module antidote protein Antitoxin
BWZ20_RS00195 27442..27744 - 303 WP_054560627.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWZ20_RS15200 27952..28536 - 585 WP_157358274.1 hypothetical protein -
BWZ20_RS00205 28743..29027 - 285 WP_042247321.1 putative addiction module antidote protein -
BWZ20_RS00210 29029..29330 - 302 Protein_40 type II toxin-antitoxin system RelE/ParE family toxin -
BWZ20_RS00215 29625..30386 - 762 WP_083677120.1 serine/threonine protein phosphatase -
BWZ20_RS00220 30531..31097 - 567 WP_198034957.1 hypothetical protein -
BWZ20_RS00225 31330..31845 - 516 WP_076614736.1 hypothetical protein -
BWZ20_RS00230 31999..32598 - 600 WP_076614738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3975..37710 33735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(2-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11663.57 Da        Isoelectric Point: 10.3063

>T72353 WP_054560627.1 NZ_CP019388:c27744-27442 [Winogradskyella sp. J14-2]
MIRTEKTSEFDKWISKLKDLRAKAKILFRIQKLESDGHFGDCKPVGDGISEMRINYAKGYRVYFKEKGNQIVVLLIGGDK
STQQKDIKKAKEIWNRIKDE

Download         Length: 303 bp

>T72353 NZ_CP019388:c27744-27442 [Winogradskyella sp. J14-2]
ATGATAAGAACCGAAAAGACATCCGAATTTGACAAGTGGATTAGTAAGCTGAAAGATTTAAGAGCGAAAGCAAAAATCCT
CTTCCGAATTCAGAAACTCGAATCGGATGGACATTTTGGAGACTGTAAACCTGTTGGAGATGGAATAAGCGAAATGCGAA
TTAATTACGCCAAAGGTTACAGAGTATATTTCAAAGAAAAAGGAAACCAAATTGTTGTTCTTTTGATTGGTGGAGATAAA
TCGACCCAACAAAAGGACATCAAAAAAGCGAAAGAAATCTGGAATAGAATAAAAGACGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10047.60 Da        Isoelectric Point: 4.7045

>AT72353 WP_054560626.1 NZ_CP019388:c27440-27156 [Winogradskyella sp. J14-2]
MATTKFDIADYLDSEEMIAEYLNTVLEDGDSSDLIVAIGHIAKAIGMTKIAEQTGMSRPSLYKALSDGAKPQFGTIMKVL
KAIGGQINVRPISA

Download         Length: 285 bp

>AT72353 NZ_CP019388:c27440-27156 [Winogradskyella sp. J14-2]
ATGGCGACAACAAAATTTGACATAGCGGATTATTTGGACAGCGAAGAAATGATTGCCGAATACTTGAATACGGTTCTTGA
AGACGGAGACAGTTCTGATTTGATTGTGGCAATCGGTCACATTGCAAAGGCAATCGGAATGACCAAAATAGCGGAACAAA
CTGGAATGAGCAGACCAAGCCTCTACAAAGCATTATCGGATGGTGCAAAACCACAGTTTGGAACCATAATGAAAGTGCTG
AAAGCAATTGGCGGACAGATAAACGTAAGACCAATATCAGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References