Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 286455..287086 Replicon chromosome
Accession NZ_CP019359
Organism Escherichia coli strain XH990

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M1UJK7
Locus tag BW242_RS03565 Protein ID WP_001259382.1
Coordinates 286455..286730 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag BW242_RS03570 Protein ID WP_000593555.1
Coordinates 286727..287086 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW242_RS03550 281459..282526 + 1068 WP_000361517.1 HlyD family secretion protein -
BW242_RS03555 282523..285258 + 2736 WP_000149130.1 ribosome-associated ATPase/putative transporter RbbA -
BW242_RS03560 285258..286382 + 1125 WP_021557290.1 ABC transporter permease -
BW242_RS03565 286455..286730 + 276 WP_001259382.1 type II toxin-antitoxin system HicA family toxin Toxin
BW242_RS03570 286727..287086 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BW242_RS03575 287136..287996 - 861 WP_021557289.1 class II aldolase -
BW242_RS03580 288028..288297 - 270 WP_000933060.1 HPr family phosphocarrier protein -
BW242_RS03585 288287..289795 - 1509 WP_021557288.1 xylulose kinase -
BW242_RS03590 289788..291146 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
BW242_RS03595 291223..291504 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
BW242_RS03600 291501..291974 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.91 Da        Isoelectric Point: 10.7076

>T72300 WP_001259382.1 NZ_CP019359:286455-286730 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T72300 NZ_CP019359:286455-286730 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT72300 WP_000593555.1 NZ_CP019359:286727-287086 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT72300 NZ_CP019359:286727-287086 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1UJK7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References