Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3524563..3525181 Replicon chromosome
Accession NZ_CP019355
Organism Escherichia coli strain XH988

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag BWZ24_RS19050 Protein ID WP_001291435.1
Coordinates 3524963..3525181 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag BWZ24_RS19045 Protein ID WP_000344800.1
Coordinates 3524563..3524937 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ24_RS19035 3519652..3520845 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BWZ24_RS19040 3520868..3524017 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
BWZ24_RS19045 3524563..3524937 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
BWZ24_RS19050 3524963..3525181 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
BWZ24_RS19055 3525353..3525904 + 552 WP_000102564.1 maltose O-acetyltransferase -
BWZ24_RS19060 3526020..3526490 + 471 WP_000136192.1 YlaC family protein -
BWZ24_RS19065 3526654..3528204 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
BWZ24_RS19070 3528246..3528599 - 354 WP_000878141.1 DUF1428 family protein -
BWZ24_RS19080 3528978..3529289 + 312 WP_000409911.1 MGMT family protein -
BWZ24_RS19085 3529320..3529892 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T72285 WP_001291435.1 NZ_CP019355:3524963-3525181 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T72285 NZ_CP019355:3524963-3525181 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT72285 WP_000344800.1 NZ_CP019355:3524563-3524937 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT72285 NZ_CP019355:3524563-3524937 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References