Detailed information of TA system TA072265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 553262..554121
• Replicon: chromosome
• Accession: NZ_CP019346
• Organism: Brucella sp. 09RB8471

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: BKD03_RS02630
• Protein ID: WP_076778465.1
• Coordinates: 553591..554121 (+)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: BKD03_RS02625
• Protein ID: WP_076779360.1
• Coordinates: 553262..553603 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKD03_RS02605	549383..550327	+	945	Protein_485	integrase arm-type DNA-binding domain-containing protein	-
BKD03_RS02610	550281..552122	+	1842	WP_083698637.1	autotransporter outer membrane beta-barrel domain-containing protein	-
BKD03_RS02615	552145..552462	-	318	WP_076778461.1	DUF736 domain-containing protein	-
BKD03_RS02620	552452..552895	+	444	WP_076778463.1	hypothetical protein	-
BKD03_RS02625	553262..553603	+	342	WP_076779360.1	DUF1778 domain-containing protein	Antitoxin
BKD03_RS02630	553591..554121	+	531	WP_076778465.1	GNAT family N-acetyltransferase	Toxin
BKD03_RS02635	554138..554629	+	492	WP_076778467.1	hypothetical protein	-
BKD03_RS02640	554854..555612	-	759	Protein_492	chromosome partitioning protein ParB	-
BKD03_RS02650	556116..557153	-	1038	WP_076778471.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
BKD03_RS02655	557146..557739	-	594	WP_076779362.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (48-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (32-107)

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 19128.93 Da
• Isoelectric Point: 7.6101

>T72265 WP_076778465.1 NZ_CP019346:553591-554121 [Brucella sp. 09RB8471]
MAEIGNKQDRPEPGLTPPVPLTAEHDLSAFDCGEPALNDWLRQRAIKNESRFSRTYVVCEGNRVVGYFCISAGAVEREAA
PGKVRRNAPDTIPVSVIGRLAVCRSRAGMGLGADLLSDALRRIALASQSIGIGAVLVHAKDDAARRFYLRCAEFIEYPVD
SRTLFLPIETVIAAFS

Nucleotide

• Length: 531 bp

>T72265 NZ_CP019346:553591-554121 [Brucella sp. 09RB8471]
ATGGCAGAAATAGGCAATAAGCAAGATCGACCCGAACCCGGCCTGACGCCTCCCGTCCCTCTAACGGCAGAGCATGACTT
GTCGGCGTTCGATTGCGGCGAACCTGCGCTGAACGATTGGCTGCGCCAGCGCGCCATAAAGAATGAAAGCCGGTTCTCGC
GCACCTATGTTGTATGCGAAGGCAACCGGGTCGTCGGCTATTTCTGCATATCGGCAGGAGCTGTTGAACGGGAAGCGGCC
CCGGGCAAGGTGCGACGCAACGCGCCCGACACGATTCCGGTCTCCGTCATAGGACGATTGGCGGTCTGTCGATCTCGTGC
GGGTATGGGCCTTGGAGCAGACCTGCTTTCGGACGCGCTACGCCGGATTGCGCTGGCATCGCAGAGCATCGGCATCGGAG
CGGTTTTGGTCCATGCCAAGGACGATGCCGCCCGGCGCTTCTATCTGCGATGCGCGGAGTTCATCGAGTATCCCGTCGAT
AGCCGAACGCTGTTCTTGCCTATCGAAACGGTGATTGCGGCCTTTAGTTAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.01 Da
• Isoelectric Point: 10.6446

>AT72265 WP_076779360.1 NZ_CP019346:553262-553603 [Brucella sp. 09RB8471]
MVKTRVASSEPARSTSAAVVGGASTSEAKGSINLRIEAGTRQLIDDAAAVLGKTRTEFMVESARRQAVDVLLDQRLFTLD
PERYDAFMQALDNPPGPGPKLRALLRRTPAWQK

Nucleotide

• Length: 342 bp

>AT72265 NZ_CP019346:553262-553603 [Brucella sp. 09RB8471]
ATGGTAAAAACGCGCGTCGCTTCTTCCGAACCTGCTCGCTCCACGTCTGCTGCTGTCGTGGGGGGTGCCTCGACGTCTGA
AGCCAAGGGCAGCATCAATCTGCGGATCGAGGCAGGCACCCGCCAACTCATTGACGACGCCGCCGCAGTTCTGGGAAAGA
CGCGCACCGAATTCATGGTCGAAAGCGCACGACGGCAAGCCGTGGATGTGCTGCTCGACCAGCGTTTGTTCACACTCGAC
CCTGAGCGCTACGATGCTTTCATGCAGGCGCTCGACAATCCGCCTGGACCGGGACCGAAGCTTAGGGCGCTGCTGCGCCG
GACTCCGGCATGGCAGAAATAG