Detailed information of TA system TA072261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3291860..3292437
• Replicon: chromosome
• Accession: NZ_CP019343
• Organism: Oceanicoccus sagamiensis strain NBRC 107125

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BST96_RS15115
• Protein ID: WP_085759506.1
• Coordinates: 3291860..3292060 (+)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BST96_RS15120
• Protein ID: WP_085759507.1
• Coordinates: 3292057..3292437 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BST96_RS15100	3288873..3289229	-	357	WP_085759504.1	response regulator	-
BST96_RS15105	3289232..3290749	-	1518	WP_085759505.1	adenylate/guanylate cyclase domain-containing response regulator	-
BST96_RS15110	3290988..3291635	+	648	WP_085760551.1	Crp/Fnr family transcriptional regulator	-
BST96_RS15115	3291860..3292060	+	201	WP_085759506.1	type II toxin-antitoxin system HicA family toxin	Toxin
BST96_RS15120	3292057..3292437	+	381	WP_085759507.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BST96_RS15125	3292440..3292829	-	390	WP_085759508.1	SirB2 family protein	-
BST96_RS15130	3292832..3294178	-	1347	WP_085759509.1	exodeoxyribonuclease VII large subunit	-
BST96_RS15135	3294433..3295902	+	1470	WP_085760552.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-51)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-121)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7425.75 Da
• Isoelectric Point: 12.2571

>T72261 WP_085759506.1 NZ_CP019343:3291860-3292060 [Oceanicoccus sagamiensis]
MPTGHGWRRVSMTGSHHHFKYPAQPGLVAVLHPKKDLPAGTVKSIIKQAGLFLPQRYLTTPRRRLS

Nucleotide

• Length: 201 bp

>T72261 NZ_CP019343:3291860-3292060 [Oceanicoccus sagamiensis]
ATGCCAACCGGGCATGGTTGGCGGCGGGTTTCTATGACTGGCAGCCACCACCACTTTAAGTATCCAGCCCAGCCAGGGTT
AGTGGCTGTGCTCCACCCGAAGAAAGATCTACCGGCTGGAACAGTGAAAAGCATTATAAAGCAGGCAGGCCTGTTTCTAC
CTCAACGATATTTAACGACGCCCAGGAGGCGCTTATCATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13559.31 Da
• Isoelectric Point: 4.3472

>AT72261 WP_085759507.1 NZ_CP019343:3292057-3292437 [Oceanicoccus sagamiensis]
MKYPVVIHHEEGSAFGLTVPDIPGCFSTGDSFDEAFDNAQEAIKDHLAILAEEGASIPAASPIAEHMDNQDFADGVWGFV
VIDISPYLGKTEKINVTLPTAMIHKIDAKYQNRSKFLAEAALAALA

Nucleotide

• Length: 381 bp

>AT72261 NZ_CP019343:3292057-3292437 [Oceanicoccus sagamiensis]
ATGAAATACCCGGTAGTCATACACCATGAAGAAGGTTCAGCCTTTGGTCTGACTGTGCCAGATATCCCCGGGTGTTTTTC
TACGGGGGACTCCTTTGATGAGGCCTTTGATAATGCCCAGGAAGCGATCAAAGACCATTTGGCGATTTTGGCTGAAGAGG
GGGCAAGTATTCCTGCGGCTTCACCCATTGCTGAGCATATGGATAACCAGGATTTTGCCGATGGTGTCTGGGGCTTTGTG
GTGATTGATATCTCCCCTTATTTGGGTAAAACCGAGAAAATCAATGTAACCCTGCCCACCGCAATGATTCATAAAATCGA
TGCCAAATACCAAAACCGTTCGAAATTTTTAGCGGAGGCAGCTTTGGCAGCGCTGGCTTAG