Detailed information of TA system TA072254

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3814704..3815511
• Replicon: chromosome
• Accession: NZ_CP019326
• Organism: Halomonas sp. 1513

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: BWR19_RS17405
• Protein ID: WP_076749549.1
• Coordinates: 3815101..3815511 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: BWR19_RS17400
• Protein ID: WP_076749548.1
• Coordinates: 3814704..3815111 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWR19_RS17365	3809710..3809976	-	267	WP_076749541.1	30S ribosomal protein S20	-
BWR19_RS17370	3810167..3811327	-	1161	WP_198034507.1	glutamate 5-kinase	-
BWR19_RS17375	3811358..3812545	-	1188	WP_076749542.1	Obg family GTPase CgtA	-
BWR19_RS17380	3812632..3812889	-	258	WP_076749544.1	50S ribosomal protein L27	-
BWR19_RS17385	3812925..3813236	-	312	WP_076749545.1	50S ribosomal protein L21	-
BWR19_RS17390	3813493..3814467	+	975	WP_076749546.1	octaprenyl diphosphate synthase	-
BWR19_RS17400	3814704..3815111	+	408	WP_076749548.1	nucleotidyltransferase domain-containing protein	Antitoxin
BWR19_RS17405	3815101..3815511	+	411	WP_076749549.1	DUF86 domain-containing protein	Toxin
BWR19_RS17410	3815521..3817164	-	1644	WP_076749551.1	GMC family oxidoreductase N-terminal domain-containing protein	-
BWR19_RS17415	3817174..3818403	-	1230	WP_076749552.1	MFS transporter	-
BWR19_RS17420	3818599..3818826	-	228	WP_076749553.1	hypothetical protein	-
BWR19_RS17425	3818962..3819762	+	801	WP_076749556.1	TlpA family protein disulfide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (16-131)

Antitoxin

• Polymerase beta, nucleotidyltransferase (12-99)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14790.88 Da
• Isoelectric Point: 6.2220

>T72254 WP_076749549.1 NZ_CP019326:3815101-3815511 [Halomonas sp. 1513]
MADDVLLNKAATIERCVARAEQEYQTAGAGFAQDFTRQDAAILNLQRACEAAIDGGSHLVRRQALGAPQSARDVFDLLVA
AGQLDAALGDVLKRMTGFRNISVHDYQKVQIPIVVAIITKHSDDLLSFARRLIELS

Nucleotide

• Length: 411 bp

>T72254 NZ_CP019326:3815101-3815511 [Halomonas sp. 1513]
ATGGCCGATGACGTGTTGCTCAACAAGGCAGCCACCATCGAGCGCTGCGTGGCTCGCGCCGAGCAGGAGTACCAAACCGC
GGGTGCAGGATTCGCCCAGGATTTTACTCGCCAGGATGCCGCCATTCTCAACCTGCAGCGCGCCTGTGAGGCGGCCATCG
ACGGCGGCTCTCACCTGGTTCGCCGCCAGGCCTTGGGCGCACCGCAGAGCGCCCGCGATGTCTTCGACTTGCTGGTTGCC
GCAGGGCAGCTCGACGCTGCGCTTGGCGACGTGCTGAAGCGCATGACGGGATTTCGCAATATTTCGGTGCACGACTACCA
GAAGGTTCAGATCCCGATCGTTGTCGCCATCATCACCAAGCATAGCGACGACTTGCTGAGTTTCGCCCGGCGGCTGATCG
AACTGAGCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15168.11 Da
• Isoelectric Point: 5.5155

>AT72254 WP_076749548.1 NZ_CP019326:3814704-3815111 [Halomonas sp. 1513]
MLTVAHQQTLTTLLRQALPSLQAVYLFGSQASGQARHDSDTDLAILLPRPADAETLWHLGDELAGALGQDVDLVDLRQAS
TVMRHQVITHGTRLWQRDQAADEFELSCLSEYWDLQIMRRGILSDIRQRGSVYGR

Nucleotide

• Length: 408 bp

>AT72254 NZ_CP019326:3814704-3815111 [Halomonas sp. 1513]
ATGCTGACGGTTGCCCACCAACAGACGTTAACCACCCTGCTACGCCAGGCGCTACCCTCACTGCAGGCCGTCTACCTGTT
CGGCAGCCAGGCCAGCGGGCAGGCCCGGCATGACAGCGACACCGACCTCGCCATCCTGCTCCCCAGGCCAGCAGACGCCG
AAACACTCTGGCACCTCGGTGACGAACTCGCCGGCGCGCTCGGGCAGGATGTCGACCTGGTCGACCTGCGCCAGGCCAGT
ACCGTGATGCGGCACCAAGTCATTACTCATGGCACCCGCCTATGGCAGCGCGACCAGGCCGCGGACGAATTCGAGCTCAG
CTGTTTGAGCGAATACTGGGACCTACAGATCATGCGCCGTGGCATTCTCTCCGATATTCGCCAGCGAGGCAGTGTCTATG
GCCGATGA