Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5528957..5529492 Replicon chromosome
Accession NZ_CP019322
Organism Methylorubrum extorquens strain PSBB040

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag BV511_RS25785 Protein ID WP_076644227.1
Coordinates 5528957..5529247 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BV511_RS25790 Protein ID WP_076644228.1
Coordinates 5529244..5529492 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV511_RS25755 5524162..5524362 + 201 WP_003605412.1 hypothetical protein -
BV511_RS25760 5524585..5525208 + 624 WP_012253132.1 TetR/AcrR family transcriptional regulator -
BV511_RS25765 5525228..5525572 - 345 WP_076644223.1 DUF1330 domain-containing protein -
BV511_RS25770 5525575..5526273 - 699 WP_076644224.1 orotidine-5'-phosphate decarboxylase -
BV511_RS25775 5526598..5528124 + 1527 WP_076644225.1 alginate export family protein -
BV511_RS25780 5528237..5528875 - 639 WP_076644226.1 uracil-DNA glycosylase family protein -
BV511_RS25785 5528957..5529247 - 291 WP_076644227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV511_RS25790 5529244..5529492 - 249 WP_076644228.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BV511_RS25795 5529626..5531128 + 1503 WP_076644229.1 glucose-6-phosphate dehydrogenase -
BV511_RS25800 5531324..5532691 + 1368 WP_076644230.1 SWIM zinc finger family protein -
BV511_RS25805 5532691..5534274 + 1584 WP_076644231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11039.62 Da        Isoelectric Point: 10.5105

>T72248 WP_076644227.1 NZ_CP019322:c5529247-5528957 [Methylorubrum extorquens]
MSVRLSPRARADLSRIWDDSAERWGADQADRYIRLLAGGFERLAEDPARGLRADEIRKGYFRLSVGSHVLFYRLGAEGGI
EVIRILHGRMDFKRHL

Download         Length: 291 bp

>T72248 NZ_CP019322:c5529247-5528957 [Methylorubrum extorquens]
ATGAGCGTCCGCCTCTCGCCGAGGGCGCGCGCGGATCTCAGCCGGATCTGGGACGATTCGGCCGAGCGCTGGGGAGCGGA
TCAGGCTGACCGCTATATCCGCCTTCTGGCCGGGGGCTTCGAGCGACTGGCCGAGGATCCGGCTCGAGGTCTGAGGGCCG
ACGAGATCCGCAAGGGGTATTTCCGCCTCTCCGTCGGATCGCACGTCCTGTTCTACCGCCTGGGCGCCGAGGGCGGCATC
GAGGTCATCCGCATCCTTCACGGGCGGATGGATTTCAAACGCCATCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9015.99 Da        Isoelectric Point: 4.4232

>AT72248 WP_076644228.1 NZ_CP019322:c5529492-5529244 [Methylorubrum extorquens]
MPRNTSVSLGEHFAQFIDRQVEGGRYGSASEVVRAGLRLLEEQEAALDTLRAALIEGEESGPPEPFDTEAFLREKREGAI
RG

Download         Length: 249 bp

>AT72248 NZ_CP019322:c5529492-5529244 [Methylorubrum extorquens]
ATGCCGCGAAACACGTCCGTCTCGCTCGGCGAGCACTTTGCGCAGTTCATCGACCGCCAGGTCGAGGGGGGGCGTTACGG
CTCCGCCAGCGAAGTCGTCCGTGCCGGACTTCGTCTCCTGGAGGAGCAGGAAGCCGCCCTCGACACGCTCCGGGCCGCGC
TGATCGAGGGGGAGGAGAGCGGCCCGCCCGAGCCCTTCGATACGGAGGCCTTTCTCCGGGAGAAGCGTGAGGGCGCGATC
CGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References