Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4683001..4683649 Replicon chromosome
Accession NZ_CP019322
Organism Methylorubrum extorquens strain PSBB040

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BV511_RS21950 Protein ID WP_076643793.1
Coordinates 4683446..4683649 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BV511_RS21945 Protein ID WP_076643792.1
Coordinates 4683001..4683408 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV511_RS21915 4678312..4678986 - 675 WP_015822797.1 DUF1275 domain-containing protein -
BV511_RS21920 4679254..4679673 + 420 WP_003599175.1 response regulator -
BV511_RS21925 4679708..4680067 + 360 WP_003599173.1 hypothetical protein -
BV511_RS21930 4680074..4680751 - 678 WP_076643789.1 dethiobiotin synthase -
BV511_RS21935 4681043..4681816 - 774 WP_076643790.1 ferredoxin--NADP reductase -
BV511_RS21940 4681986..4682918 - 933 WP_076643791.1 ring-cleaving dioxygenase -
BV511_RS21945 4683001..4683408 - 408 WP_076643792.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BV511_RS21950 4683446..4683649 - 204 WP_076643793.1 type II toxin-antitoxin system HicA family toxin Toxin
BV511_RS21955 4683861..4685144 - 1284 WP_076643794.1 insulinase family protein -
BV511_RS21960 4685216..4686598 - 1383 WP_076643795.1 insulinase family protein -
BV511_RS21965 4686791..4687495 - 705 WP_076643796.1 hypothetical protein -
BV511_RS21970 4687658..4688173 - 516 WP_076643797.1 signal peptidase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-126)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7738.77 Da        Isoelectric Point: 11.4362

>T72247 WP_076643793.1 NZ_CP019322:c4683649-4683446 [Methylorubrum extorquens]
VSNRDKETRGLIVRLRDDGWIVARKGPGDHVQYKHPTKPGRVTLDTGRREQALGTLRSIFRQAGWEW

Download         Length: 204 bp

>T72247 NZ_CP019322:c4683649-4683446 [Methylorubrum extorquens]
GTGTCGAATCGCGACAAGGAAACGCGCGGCCTCATAGTCCGACTGCGCGATGATGGTTGGATCGTTGCCCGGAAGGGGCC
GGGCGACCATGTCCAGTACAAACATCCAACGAAACCGGGACGTGTGACGCTGGATACCGGGCGCCGCGAGCAGGCGCTGG
GTACGCTCCGCAGCATCTTCCGGCAGGCGGGGTGGGAATGGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14484.48 Da        Isoelectric Point: 4.6843

>AT72247 WP_076643792.1 NZ_CP019322:c4683408-4683001 [Methylorubrum extorquens]
MTRVVMLIHGEAGNYGASFPDFPGATTGADDLDELYRKAAEMLAFHVGGLVEDGEPVPRARSLEELRGDPVFIEESRDAM
IGLIEVDLPGRAVRVNISVEESLLKRIDRAAKAAGESRSGFLAQAAKARLTSMVA

Download         Length: 408 bp

>AT72247 NZ_CP019322:c4683408-4683001 [Methylorubrum extorquens]
ATGACGCGGGTCGTCATGTTGATCCACGGCGAAGCCGGCAATTACGGCGCCTCATTCCCGGATTTTCCCGGTGCGACGAC
GGGCGCCGACGATCTCGACGAACTCTACCGGAAGGCCGCCGAGATGCTGGCTTTCCATGTCGGCGGCTTGGTGGAGGATG
GCGAACCGGTGCCGCGGGCCCGTTCGCTGGAAGAACTGCGCGGCGACCCCGTTTTCATCGAGGAAAGCCGGGACGCGATG
ATCGGCCTGATCGAGGTCGATCTCCCGGGGCGTGCCGTCCGGGTGAACATCTCGGTCGAGGAGAGTCTGCTCAAGCGTAT
CGACCGCGCGGCCAAGGCCGCCGGCGAGAGCCGATCCGGCTTCCTCGCGCAGGCCGCGAAGGCGCGCCTGACGTCCATGG
TGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References