Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3999259..3999854 Replicon chromosome
Accession NZ_CP019322
Organism Methylorubrum extorquens strain PSBB040

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag BV511_RS18980 Protein ID WP_076643462.1
Coordinates 3999564..3999854 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag BV511_RS18975 Protein ID WP_076643461.1
Coordinates 3999259..3999561 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV511_RS18955 3995350..3996378 + 1029 WP_076643458.1 alpha/beta hydrolase -
BV511_RS18960 3996477..3997088 + 612 WP_076643459.1 phosphatase PAP2 family protein -
BV511_RS18965 3997275..3997502 - 228 WP_003603049.1 hypothetical protein -
BV511_RS18970 3997672..3999237 + 1566 WP_076643460.1 glutamine-hydrolyzing GMP synthase -
BV511_RS18975 3999259..3999561 - 303 WP_076643461.1 putative addiction module antidote protein Antitoxin
BV511_RS18980 3999564..3999854 - 291 WP_076643462.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV511_RS18985 4000184..4001017 + 834 WP_076643463.1 ABC transporter substrate-binding protein -
BV511_RS18990 4001014..4002054 + 1041 WP_076643464.1 iron ABC transporter permease -
BV511_RS27360 4002051..4002854 + 804 Protein_3698 ABC transporter ATP-binding protein -
BV511_RS27365 4002876..4003796 + 921 WP_196774000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10675.34 Da        Isoelectric Point: 10.2219

>T72246 WP_076643462.1 NZ_CP019322:c3999854-3999564 [Methylorubrum extorquens]
MPTIRRTSVFQTWIDDLRDVRAVARIAKRIDRLALGNPGDVKPVGDGVSEMRIDYGPGYRVYFTAQGKQIVILLCGGDKS
SQERDIRAAKALAKEL

Download         Length: 291 bp

>T72246 NZ_CP019322:c3999854-3999564 [Methylorubrum extorquens]
ATGCCGACGATCCGCCGTACGAGTGTCTTTCAGACTTGGATCGACGATTTGCGCGACGTTCGCGCCGTTGCTCGCATCGC
CAAGCGCATCGATCGGTTGGCGCTCGGCAATCCGGGCGACGTCAAACCGGTTGGAGACGGTGTCAGCGAGATGCGGATCG
ATTACGGCCCCGGCTACCGGGTCTACTTCACCGCCCAAGGCAAGCAGATCGTCATTTTGCTTTGCGGTGGAGATAAGAGC
TCACAGGAGCGGGACATCCGAGCTGCGAAAGCGCTCGCGAAGGAGCTTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10977.50 Da        Isoelectric Point: 5.5368

>AT72246 WP_076643461.1 NZ_CP019322:c3999561-3999259 [Methylorubrum extorquens]
MALETQPYDSAEHLKTPEHIAAYLDAVLEDNDPALLAHALGVIARARGMTQIAQDVGRSREQLYRTLSDKGNPQLDTLMG
VLKSLGLRLSVHPIEMDRSA

Download         Length: 303 bp

>AT72246 NZ_CP019322:c3999561-3999259 [Methylorubrum extorquens]
ATGGCCCTCGAAACGCAGCCTTACGACAGCGCCGAGCACCTGAAGACGCCCGAACACATCGCGGCCTATCTCGATGCCGT
GCTGGAAGATAACGATCCCGCACTACTCGCCCACGCGCTCGGTGTCATCGCGCGCGCCCGCGGAATGACGCAGATCGCTC
AGGACGTCGGCCGGTCGCGAGAACAACTCTATCGAACCTTGTCCGATAAGGGGAACCCGCAACTCGACACGCTCATGGGT
GTGCTGAAGTCGTTAGGATTGCGCCTCAGCGTGCATCCGATCGAGATGGACCGGTCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References