Detailed information of TA system TA072245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1525114..1525757
• Replicon: chromosome
• Accession: NZ_CP019322
• Organism: Methylorubrum extorquens strain PSBB040

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BV511_RS07245
• Protein ID: WP_076641601.1
• Coordinates: 1525353..1525757 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BV511_RS07240
• Protein ID: WP_076641600.1
• Coordinates: 1525114..1525353 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV511_RS07225	1521768..1522454	-	687	WP_003598308.1	hypothetical protein	-
BV511_RS07230	1522770..1523108	+	339	WP_076641598.1	hypothetical protein	-
BV511_RS07235	1523164..1525011	-	1848	WP_076641599.1	DNA helicase RecQ	-
BV511_RS07240	1525114..1525353	+	240	WP_076641600.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BV511_RS07245	1525353..1525757	+	405	WP_076641601.1	type II toxin-antitoxin system VapC family toxin	Toxin
BV511_RS07250	1525761..1526915	-	1155	WP_012251832.1	DNA replication/repair protein RecF	-
BV511_RS07255	1526956..1528077	-	1122	WP_076641602.1	DNA polymerase III subunit beta	-
BV511_RS07260	1528400..1529905	-	1506	WP_012251830.1	chromosomal replication initiator protein DnaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-128)

Antitoxin

• Antitoxin VapB-like (1-75)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14280.29 Da
• Isoelectric Point: 5.1418

>T72245 WP_076641601.1 NZ_CP019322:1525353-1525757 [Methylorubrum extorquens]
MFVDASAIVAIIAREPQAETLTARLEEAPVRYTSAVAVLETVMALRRLGAGSVAQAEQLVRHLLEHADIEEVPITTRESA
AAIAAYARYGKGQGHPAQLNLGDCFAYACARTRNVPLLFVGNDFSQTDIAAALA

Nucleotide

• Length: 405 bp

>T72245 NZ_CP019322:1525353-1525757 [Methylorubrum extorquens]
ATGTTCGTAGACGCGTCGGCGATCGTCGCGATCATCGCACGCGAGCCGCAGGCGGAAACATTGACAGCCAGGCTCGAGGA
GGCGCCCGTCCGCTACACCTCGGCAGTGGCCGTCTTGGAAACGGTGATGGCCTTGCGGCGCCTTGGTGCGGGATCGGTCG
CGCAAGCAGAGCAACTGGTGCGACATCTGCTCGAGCATGCGGATATTGAGGAAGTCCCCATCACAACGCGGGAGTCGGCT
GCGGCCATCGCCGCATACGCGCGCTACGGCAAAGGCCAGGGCCATCCTGCTCAACTCAACCTCGGCGACTGCTTCGCCTA
TGCCTGCGCTCGAACGCGCAATGTCCCGCTTCTCTTCGTCGGCAACGACTTCTCGCAGACCGACATCGCCGCTGCATTGG
CCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8959.23 Da
• Isoelectric Point: 10.0862

>AT72245 WP_076641600.1 NZ_CP019322:1525114-1525353 [Methylorubrum extorquens]
MPLNIRSEEVNRLAEKLASQARVSKTEAVRMALANELQRRESSLPLSERIKPIQDAFARWPKTGLKADKAFFDDMNGES

Nucleotide

• Length: 240 bp

>AT72245 NZ_CP019322:1525114-1525353 [Methylorubrum extorquens]
ATGCCCTTGAACATCCGCAGCGAGGAGGTGAACCGCCTCGCCGAGAAGCTGGCATCGCAGGCTCGGGTGAGCAAGACCGA
GGCGGTGCGTATGGCGTTGGCCAACGAACTGCAACGCCGGGAATCGTCGCTGCCGCTGTCAGAGCGGATCAAGCCGATCC
AAGATGCCTTCGCGCGTTGGCCGAAGACGGGTCTGAAAGCCGACAAGGCCTTCTTCGACGACATGAACGGCGAGTCCTGA