Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1415391..1415950 Replicon chromosome
Accession NZ_CP019321
Organism Vibrio vulnificus strain VV2014DJH

Toxin (Protein)


Gene name relE Uniprot ID A0A3Q0L0M9
Locus tag BWZ32_RS22545 Protein ID WP_011082349.1
Coordinates 1415391..1415669 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3Q0L0M2
Locus tag BWZ32_RS22550 Protein ID WP_011082348.1
Coordinates 1415666..1415950 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ32_RS22515 1411262..1411726 + 465 WP_015727544.1 hypothetical protein -
BWZ32_RS22520 1411763..1412386 + 624 WP_045596970.1 hypothetical protein -
BWZ32_RS22525 1412502..1413017 + 516 WP_045619818.1 lipocalin family protein -
BWZ32_RS22530 1413473..1413901 + 429 WP_101957855.1 hypothetical protein -
BWZ32_RS22535 1414068..1415267 + 1200 WP_040110527.1 hypothetical protein -
BWZ32_RS22540 1415273..1415362 + 90 WP_204250646.1 DUF3265 domain-containing protein -
BWZ32_RS22545 1415391..1415669 - 279 WP_011082349.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWZ32_RS22550 1415666..1415950 - 285 WP_011082348.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BWZ32_RS22555 1416184..1416993 + 810 WP_039452822.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
BWZ32_RS22560 1417233..1417496 + 264 WP_011082346.1 hypothetical protein -
BWZ32_RS22565 1417573..1418073 + 501 WP_101957856.1 hypothetical protein -
BWZ32_RS22570 1418153..1419178 - 1026 WP_197672410.1 L-threonine 3-dehydrogenase -
BWZ32_RS22575 1419425..1420618 - 1194 WP_011082341.1 glycine C-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10932.66 Da        Isoelectric Point: 4.2397

>T72244 WP_011082349.1 NZ_CP019321:c1415669-1415391 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDVPEKTDNLIEAKVENLLEQPLMGVQRDSILGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T72244 NZ_CP019321:c1415669-1415391 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGTGCC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCTCGGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT72244 WP_011082348.1 NZ_CP019321:c1415950-1415666 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT72244 NZ_CP019321:c1415950-1415666 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L0M9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L0M2

References