Detailed information of TA system TA072243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2645933..2647494
• Replicon: chromosome
• Accession: NZ_CP019320
• Organism: Vibrio vulnificus strain VV2014DJH

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1W6M5G8
• Locus tag: BWZ32_RS13465
• Protein ID: WP_069504143.1
• Coordinates: 2645933..2647261 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: BWZ32_RS13470
• Protein ID: WP_025787161.1
• Coordinates: 2647255..2647494 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWZ32_RS13445	2641121..2641585	-	465	WP_011079944.1	DUF2846 domain-containing protein	-
BWZ32_RS13450	2641786..2642838	-	1053	WP_101957227.1	diguanylate cyclase	-
BWZ32_RS13455	2642976..2643734	-	759	WP_011079942.1	magnesium transporter	-
BWZ32_RS13460	2644419..2645741	+	1323	WP_101957228.1	site-specific integrase	-
BWZ32_RS13465	2645933..2647261	-	1329	WP_069504143.1	type II toxin-antitoxin system HipA family toxin	Toxin
BWZ32_RS13470	2647255..2647494	-	240	WP_025787161.1	helix-turn-helix domain-containing protein	Antitoxin
BWZ32_RS13475	2647989..2649830	+	1842	WP_101957229.1	DUF262 domain-containing protein	-
BWZ32_RS13480	2649823..2652273	+	2451	WP_101957230.1	DUF262 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2645933..2671978	26045

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49723.13 Da
• Isoelectric Point: 8.5824

>T72243 WP_069504143.1 NZ_CP019320:c2647261-2645933 [Vibrio vulnificus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSGWVLAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KAETKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRTITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
SMAMEVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T72243 NZ_CP019320:c2647261-2645933 [Vibrio vulnificus]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGGTTGGGTTTTAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAATCAACAGATACGAGATAGAATAGCTGCCCGCTAT
AAAGCAGAGACTAAACAGCCATTCGACCTATTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGCTAGTTCCAGA
GGGCTTTGATGTAGATGATCATCGAACCATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGACGCTCCTTTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTGTTTCACGATGGAAGATGGATGCTACCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCTAGTGTCGATAATGAGTTGATTTGTATGAGGCTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCTGTTGAGCGATTTGACCGA
AAATTATCTTCTGATAACAGCTATTACTTGCGCTTGCCCCATGAGGATTTTTGCCAGGCAAAAGGGATTCCCTCAGCTAG
AAAATATGAAATTGACGGTGGTATCGGCATAGAAGAATCTATTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATCTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGGCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTCGATGAGTTTGAA
TCGATGGCAATGGAGGTGATTGATTCTGTCGGAAACTCGCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAAATTCAATTGACAAAAAAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.02 Da
• Isoelectric Point: 7.2039

>AT72243 WP_025787161.1 NZ_CP019320:c2647494-2647255 [Vibrio vulnificus]
MLVNTPTALGNALREARKESGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHIIETKGAVDEW

Nucleotide

• Length: 240 bp

>AT72243 NZ_CP019320:c2647494-2647255 [Vibrio vulnificus]
ATGCTAGTCAACACACCGACAGCTCTCGGCAATGCGTTACGCGAAGCCCGAAAGGAAAGCGGCCTAAAGCAAACAGATCT
TGGTCTGCGACAAGCAACAGTATCTAATTTTGAAAGCAATCCTGAAAAATCCACGATAGAAACATTGTTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCGAAAGGCAAGCACATTATTGAAACTAAAGGGGCTGTTGACGAATGGTGA

Structures

Toxin

• AlphaFold DB: A0A1W6M5G8