Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2130441..2130957 Replicon chromosome
Accession NZ_CP019320
Organism Vibrio vulnificus strain VV2014DJH

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag BWZ32_RS10700 Protein ID WP_005464459.1
Coordinates 2130441..2130710 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U2ZH00
Locus tag BWZ32_RS10705 Protein ID WP_005526636.1
Coordinates 2130703..2130957 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ32_RS10650 2125743..2125835 - 93 WP_017045846.1 DUF3265 domain-containing protein -
BWZ32_RS10655 2125862..2126350 - 489 WP_029842472.1 hypothetical protein -
BWZ32_RS10660 2126360..2126497 - 138 WP_101957413.1 DUF3265 domain-containing protein -
BWZ32_RS10665 2126579..2127547 + 969 WP_080726343.1 IS30-like element ISVa6 family transposase -
BWZ32_RS10670 2127582..2127839 - 258 WP_053543562.1 hypothetical protein -
BWZ32_RS10675 2128408..2128794 - 387 WP_101957057.1 hypothetical protein -
BWZ32_RS10680 2128791..2128922 - 132 WP_101957058.1 DUF3265 domain-containing protein -
BWZ32_RS10685 2128940..2129260 - 321 WP_101956984.1 DUF2834 domain-containing protein -
BWZ32_RS10690 2129294..2129416 - 123 WP_101957414.1 DUF3265 domain-containing protein -
BWZ32_RS10695 2129459..2130184 - 726 WP_158297235.1 GNAT family N-acetyltransferase -
BWZ32_RS10700 2130441..2130710 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
BWZ32_RS10705 2130703..2130957 - 255 WP_005526636.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BWZ32_RS10710 2131049..2131171 - 123 WP_204250600.1 DUF3265 domain-containing protein -
BWZ32_RS10715 2131531..2131641 - 111 WP_080553514.1 DUF3265 domain-containing protein -
BWZ32_RS10720 2131666..2131959 - 294 WP_043921026.1 hypothetical protein -
BWZ32_RS24330 2131986..2132075 - 90 Protein_1985 DUF3265 domain-containing protein -
BWZ32_RS10730 2132197..2132412 - 216 WP_162299002.1 hypothetical protein -
BWZ32_RS10740 2132711..2133148 - 438 WP_039470159.1 hypothetical protein -
BWZ32_RS10745 2133163..2133312 - 150 Protein_1988 DUF3265 domain-containing protein -
BWZ32_RS10750 2133321..2133656 - 336 WP_103193443.1 hypothetical protein -
BWZ32_RS10755 2133807..2134967 - 1161 WP_146180998.1 hypothetical protein -
BWZ32_RS10760 2135020..2135109 - 90 WP_072833196.1 DUF3265 domain-containing protein -
BWZ32_RS10765 2135176..2135469 - 294 WP_017191337.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2020149..2214577 194428
- inside Integron - - 2026349..2214577 188228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T72242 WP_005464459.1 NZ_CP019320:c2130710-2130441 [Vibrio vulnificus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T72242 NZ_CP019320:c2130710-2130441 [Vibrio vulnificus]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTCTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCCCCATTTGAGGGCATCGGTAAACCAGAGCCGTTAA
AAGAAAACTTGTCTGGTTTTTGGTCTCGTCGTATTGATGATACTAACAGGCTTGTTTATGCAGTTGATGATCAAGCGATT
ACGATAATTTCGTGCCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 5.0623

>AT72242 WP_005526636.1 NZ_CP019320:c2130957-2130703 [Vibrio vulnificus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT72242 NZ_CP019320:c2130957-2130703 [Vibrio vulnificus]
ATGAGAATTGTATCTTTTACTGAAGCTAGAAATGGTCTCAAGGCTGTTTTGGACGGTGTAGTTAATGACGCCGATACGAC
AGTTATTACCCGCCGTGATTCTGAAGATGCAGTGGTTATGTCGTTAGACTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAATGCCGAACACTTAAACCGTTCGATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A244CM06

References