Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 2119563..2120128 Replicon chromosome
Accession NZ_CP019320
Organism Vibrio vulnificus strain VV2014DJH

Toxin (Protein)


Gene name relE Uniprot ID I3NI62
Locus tag BWZ32_RS10600 Protein ID WP_011080400.1
Coordinates 2119563..2119850 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3NI65
Locus tag BWZ32_RS10605 Protein ID WP_011080399.1
Coordinates 2119847..2120128 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ32_RS10550 2114892..2115323 - 432 WP_045587970.1 NUDIX domain-containing protein -
BWZ32_RS10555 2115293..2115463 - 171 WP_101957048.1 DUF3265 domain-containing protein -
BWZ32_RS10560 2115806..2116084 - 279 Protein_1955 DUF3265 domain-containing protein -
BWZ32_RS10565 2116332..2116487 - 156 WP_101957049.1 DUF3265 domain-containing protein -
BWZ32_RS10575 2116847..2116957 - 111 WP_101957410.1 DUF3265 domain-containing protein -
BWZ32_RS10580 2117425..2117787 - 363 WP_101957050.1 hypothetical protein -
BWZ32_RS10585 2117732..2117893 - 162 WP_101957051.1 DUF3265 domain-containing protein -
BWZ32_RS10590 2117937..2118299 - 363 WP_204250566.1 DUF4144 domain-containing protein -
BWZ32_RS10600 2119563..2119850 - 288 WP_011080400.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWZ32_RS10605 2119847..2120128 - 282 WP_011080399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BWZ32_RS24105 2120331..2121089 - 759 WP_158297242.1 hypothetical protein -
BWZ32_RS10610 2121691..2122110 - 420 WP_101957054.1 hypothetical protein -
BWZ32_RS10615 2122289..2122579 - 291 WP_045620449.1 hypothetical protein -
BWZ32_RS10620 2122592..2122753 - 162 Protein_1966 DUF3265 domain-containing protein -
BWZ32_RS10625 2122850..2123818 + 969 WP_080726343.1 IS30-like element ISVa6 family transposase -
BWZ32_RS10630 2123859..2124188 - 330 WP_101957055.1 hypothetical protein -
BWZ32_RS10635 2124332..2124880 - 549 WP_204250567.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2020149..2214577 194428
- inside Integron - - 2026349..2214577 188228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.69 Da        Isoelectric Point: 5.0872

>T72241 WP_011080400.1 NZ_CP019320:c2119850-2119563 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPVAAESWVNEVFDKTELLSNMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQMLTESDV

Download         Length: 288 bp

>T72241 NZ_CP019320:c2119850-2119563 [Vibrio vulnificus]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCACTGGATAACCCAGTGGC
AGCAGAAAGCTGGGTTAATGAAGTTTTCGATAAAACCGAACTTCTCTCAAATATGCCTGAAATGGGGCGAATGGTTCCTG
AGTTACCTCATACTAATTATCGTGAAATCCTTTTTGGCCACTACCGAATCATATATAGCCTCAGTCATGAAATTCGTGTC
CTGACAGTAAGAAATTGTCGTCAAATGCTAACGGAAAGTGATGTGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10426.96 Da        Isoelectric Point: 5.8719

>AT72241 WP_011080399.1 NZ_CP019320:c2120128-2119847 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Download         Length: 282 bp

>AT72241 NZ_CP019320:c2120128-2119847 [Vibrio vulnificus]
ATGAGCCGTATCCACTTTGACCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGTAGACCATTAGTAATCACACAACGTGGTAAGGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAGGAGAAGATCGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAATTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGCGCTCAAGTGTTGGGGCGTATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L634

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0MQY5

References