Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2111290..2111828 Replicon chromosome
Accession NZ_CP019320
Organism Vibrio vulnificus strain VV2014DJH

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag BWZ32_RS10495 Protein ID WP_001247271.1
Coordinates 2111529..2111828 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag BWZ32_RS10490 Protein ID WP_011080384.1
Coordinates 2111290..2111532 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ32_RS10420 2106547..2106675 - 129 WP_101957404.1 DUF3265 domain-containing protein -
BWZ32_RS10425 2107029..2107121 - 93 WP_204250565.1 DUF3265 domain-containing protein -
BWZ32_RS10430 2107145..2107951 - 807 WP_101957042.1 hypothetical protein -
BWZ32_RS10435 2107957..2108127 - 171 WP_101957043.1 DUF3265 domain-containing protein -
BWZ32_RS10445 2108470..2108562 - 93 Protein_1938 DUF3265 domain-containing protein -
BWZ32_RS10450 2108589..2109038 - 450 WP_011080340.1 GNAT family N-acetyltransferase -
BWZ32_RS10455 2109039..2109155 - 117 WP_101957406.1 DUF3265 domain-containing protein -
BWZ32_RS10465 2109649..2110074 - 426 WP_072611534.1 hypothetical protein -
BWZ32_RS10470 2110116..2110226 - 111 WP_101957410.1 DUF3265 domain-containing protein -
BWZ32_RS10480 2110695..2111087 - 393 WP_011080347.1 hypothetical protein -
BWZ32_RS10485 2111103..2111225 - 123 WP_101957407.1 DUF3265 domain-containing protein -
BWZ32_RS10490 2111290..2111532 + 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BWZ32_RS10495 2111529..2111828 + 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWZ32_RS10500 2111762..2111947 - 186 WP_101957046.1 DUF3265 domain-containing protein -
BWZ32_RS10505 2112291..2112419 - 129 WP_101957408.1 DUF3265 domain-containing protein -
BWZ32_RS10520 2113240..2113632 - 393 WP_101957047.1 hypothetical protein -
BWZ32_RS10525 2113716..2113850 - 135 WP_181390819.1 DUF3265 domain-containing protein -
BWZ32_RS10535 2114188..2114280 - 93 Protein_1951 DUF3265 domain-containing protein -
BWZ32_RS10540 2114307..2114756 - 450 WP_011080340.1 GNAT family N-acetyltransferase -
BWZ32_RS10550 2114892..2115323 - 432 WP_045587970.1 NUDIX domain-containing protein -
BWZ32_RS10555 2115293..2115463 - 171 WP_101957048.1 DUF3265 domain-containing protein -
BWZ32_RS10560 2115806..2116084 - 279 Protein_1955 DUF3265 domain-containing protein -
BWZ32_RS10565 2116332..2116487 - 156 WP_101957049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2020149..2214577 194428
- inside Integron - - 2026349..2214577 188228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T72240 WP_001247271.1 NZ_CP019320:2111529-2111828 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T72240 NZ_CP019320:2111529-2111828 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGCTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT72240 WP_011080384.1 NZ_CP019320:2111290-2111532 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT72240 NZ_CP019320:2111290-2111532 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGGCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References