Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1053308..1055136 Replicon chromosome
Accession NZ_CP019320
Organism Vibrio vulnificus strain VV2014DJH

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BWZ32_RS05070 Protein ID WP_043877077.1
Coordinates 1053775..1055136 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BWZ32_RS05065 Protein ID WP_101956734.1
Coordinates 1053308..1053790 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWZ32_RS05045 1049321..1049875 + 555 WP_011078504.1 hypothetical protein -
BWZ32_RS05050 1049877..1050632 + 756 WP_045598202.1 NRDE family protein -
BWZ32_RS05055 1050647..1051084 + 438 WP_011078502.1 YHS domain-containing protein -
BWZ32_RS05060 1051127..1052869 + 1743 WP_101956733.1 lysophospholipid acyltransferase family protein -
BWZ32_RS05065 1053308..1053790 - 483 WP_101956734.1 helix-turn-helix domain-containing protein Antitoxin
BWZ32_RS05070 1053775..1055136 - 1362 WP_043877077.1 type II toxin-antitoxin system HipA family toxin Toxin
BWZ32_RS05080 1056022..1056507 - 486 WP_011078466.1 SsrA-binding protein SmpB -
BWZ32_RS05085 1056623..1057054 + 432 WP_026050324.1 ubiquinone-binding protein -
BWZ32_RS05090 1057051..1057404 + 354 WP_011078464.1 RnfH family protein -
BWZ32_RS05095 1057500..1057859 - 360 WP_061058293.1 outer membrane protein assembly factor BamE -
BWZ32_RS05100 1058038..1059702 - 1665 WP_061058294.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51446.22 Da        Isoelectric Point: 4.8137

>T72239 WP_043877077.1 NZ_CP019320:c1055136-1053775 [Vibrio vulnificus]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFNDMGKPGWLKFLDDIM
PSGASRRYWVRYLDIEDLSSDEQDYVLLKFGTMSPVGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYALQRGAAA
GGATGAGGEAPKLILRCGLDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFIGIADTLSDLV
PKEVLLQELEITASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T72239 NZ_CP019320:c1055136-1053775 [Vibrio vulnificus]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAAGTGAATGGATAGACATTGGTATCATCTCATTCCCAAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTAATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGCGGCGCTAGTAGACGGTACTGGGTCAGATATCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTGTTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACTGCAAAGGGGCGCAGCCGCG
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTCTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCAGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTAATGAGCA
GCAAATCGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCATTAGAGGTTGGCGGAACTTACGACTTCATCGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAGGTGTTATTACAAGAGCTAGAGATTACTGCAAGTAAATGCATTGACTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17565.08 Da        Isoelectric Point: 10.8446

>AT72239 WP_101956734.1 NZ_CP019320:c1053790-1053308 [Vibrio vulnificus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDSEAG

Download         Length: 483 bp

>AT72239 NZ_CP019320:c1053790-1053308 [Vibrio vulnificus]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
CGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTGCTAATAGATAGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References