Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2501872..2502434 Replicon chromosome
Accession NZ_CP019305
Organism Lacticaseibacillus rhamnosus strain SCT-10-10-60

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag BWQ99_RS12535 Protein ID WP_005692155.1
Coordinates 2501872..2502219 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BWQ99_RS12540 Protein ID WP_014571589.1
Coordinates 2502219..2502434 (-) Length 72 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWQ99_RS12505 2497367..2498608 - 1242 WP_005692160.1 acyltransferase -
BWQ99_RS12510 2498605..2499306 - 702 WP_005692159.1 ABC transporter ATP-binding protein -
BWQ99_RS12515 2499299..2500117 - 819 WP_014571588.1 ABC transporter permease subunit -
BWQ99_RS12520 2500358..2501026 - 669 WP_005692157.1 tRNA ligase -
BWQ99_RS12525 2501206..2501349 + 144 WP_015764720.1 hypothetical protein -
BWQ99_RS12535 2501872..2502219 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BWQ99_RS12540 2502219..2502434 - 216 WP_014571589.1 hypothetical protein Antitoxin
BWQ99_RS12545 2502531..2504366 - 1836 WP_015764721.1 ABC transporter ATP-binding protein/permease -
BWQ99_RS12550 2504353..2506143 - 1791 WP_015764722.1 ABC transporter ATP-binding protein/permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-90)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T72234 WP_005692155.1 NZ_CP019305:c2502219-2501872 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

>T72234 NZ_CP019305:c2502219-2501872 [Lacticaseibacillus rhamnosus]
ATGACATATAAGGCTAAGCAAGGTGATGTGGTGTGGCTTGATTTTGATCCGTCCGAGGGTCATGAAATTAGAAAAAGATG
CCCAGCTGTTGTTTTAAGCAGTAACGCATACAATCGTGCAACCGGATTTGTGATTGTCGCACCAATTACCTCAACAATTC
GGACACTACCTGGTTATGTTGATATTGTATCCAATAAAATTCGTGGTCAGGTTGTCACTTCGCAGGTTTATTCTCTGGAT
GTCACTGAACAAGGCAACCGAAAAATCGATTTTATTGAAAGAATGAACATTGAAGATTTTTATACAGTCGCTCAATTCAC
CAAAATGAATTTTGATTTTAAATTTTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7986.13 Da        Isoelectric Point: 5.7995

>AT72234 WP_014571589.1 NZ_CP019305:c2502434-2502219 [Lacticaseibacillus rhamnosus]
MDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 216 bp

>AT72234 NZ_CP019305:c2502434-2502219 [Lacticaseibacillus rhamnosus]
ATGGATGTGAAAGTTGTAAAACGTGGAAACTCGTTAGCTTTATCACTTCCGAGCAGTGCGGGTTTCAAACGAGGCGAGGC
GTTTTTGCTGATTTCAGATGAAAAAGGTGGTTATCTGTTGATCCCAAAGGTAAAAAATCCCTATACCAAAGCAAAACCAT
TATCATTCCATCAAGAAGAAGCTTGGCCGGATTTTGACTATGAGGATATTGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75


Antitoxin

Source ID Structure

References