Detailed information of TA system TA072232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1062277..1062803
• Replicon: chromosome
• Accession: NZ_CP019304
• Organism: Arthrobacter sp. QXT-31

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BWQ92_RS04795
• Protein ID: WP_076798531.1
• Coordinates: 1062277..1062603 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: BWQ92_RS04800
• Protein ID: WP_076798532.1
• Coordinates: 1062600..1062803 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWQ92_RS04785	1059495..1060736	+	1242	WP_076798529.1	DUF3322 and DUF2220 domain-containing protein	-
BWQ92_RS04790	1060733..1061962	-	1230	WP_076798530.1	ATP-binding protein	-
BWQ92_RS04795	1062277..1062603	-	327	WP_076798531.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BWQ92_RS04800	1062600..1062803	-	204	WP_076798532.1	antitoxin MazE family protein	Antitoxin
BWQ92_RS04805	1062928..1063710	+	783	WP_076798533.1	GntR family transcriptional regulator	-
BWQ92_RS04810	1063764..1065005	-	1242	WP_076798534.1	S8 family serine peptidase	-
BWQ92_RS04815	1065194..1066486	-	1293	WP_076798535.1	S8 family peptidase	-
BWQ92_RS04820	1066706..1067080	+	375	WP_076798536.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-106)

Antitoxin

• Antitoxin MazE-like (4-65)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11769.63 Da
• Isoelectric Point: 7.0121

>T72232 WP_076798531.1 NZ_CP019304:c1062603-1062277 [Arthrobacter sp. QXT-31]
VNRGELWTVSGGTYAQKPRPALIIQDDLFEASESVTLLPLTSHLTDAPLLRLTVEPGQLTGLELVSQIMVDKLTTVRRSN
LGQRIGRIDSKTMVAVEQSLAVFLGLGR

Nucleotide

• Length: 327 bp

>T72232 NZ_CP019304:c1062603-1062277 [Arthrobacter sp. QXT-31]
GTGAATCGCGGTGAGCTGTGGACGGTGTCCGGCGGAACGTATGCGCAGAAGCCCCGACCCGCACTCATCATTCAGGATGA
CCTTTTCGAAGCGTCGGAGTCGGTCACGCTCCTGCCGCTGACGTCCCATCTGACTGACGCCCCGCTCCTGAGGCTGACGG
TGGAACCGGGGCAGCTCACCGGTTTGGAACTCGTCAGCCAGATTATGGTGGACAAGCTGACAACAGTCCGTCGCAGTAAC
CTGGGGCAGCGGATAGGCCGAATAGATTCCAAAACGATGGTTGCAGTTGAACAATCCCTTGCCGTCTTTCTCGGGCTGGG
GCGCTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 8015.96 Da
• Isoelectric Point: 5.8433

>AT72232 WP_076798532.1 NZ_CP019304:c1062803-1062600 [Arthrobacter sp. QXT-31]
MSVRDRVARHRIAMRERGFRQIQMWVPDVRTEKFRDEARRQALAVAASDRATDDQDFVEQIAEDWPE

Nucleotide

• Length: 204 bp

>AT72232 NZ_CP019304:c1062803-1062600 [Arthrobacter sp. QXT-31]
ATGAGCGTAAGGGATCGGGTTGCACGGCACCGGATTGCCATGCGTGAGCGCGGATTCCGGCAGATTCAGATGTGGGTGCC
GGATGTGCGCACGGAGAAGTTTAGGGACGAAGCGCGACGCCAGGCGCTGGCCGTTGCCGCTTCGGACCGGGCGACGGACG
ACCAGGATTTCGTCGAACAGATTGCGGAAGACTGGCCGGAGTGA