Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1136396..1136894 Replicon chromosome
Accession NZ_CP019299
Organism Streptococcus pneumoniae strain HKU1-14

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag BWQ98_RS06015 Protein ID WP_001823540.1
Coordinates 1136396..1136650 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag BWQ98_RS06020 Protein ID WP_000208080.1
Coordinates 1136652..1136894 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWQ98_RS06000 1131665..1134133 - 2469 WP_001152990.1 DNA gyrase subunit A -
BWQ98_RS06005 1134327..1135313 + 987 WP_000204727.1 L-lactate dehydrogenase -
BWQ98_RS06010 1135576..1136349 - 774 WP_000725951.1 ion transporter -
BWQ98_RS06015 1136396..1136650 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWQ98_RS06020 1136652..1136894 - 243 WP_000208080.1 hypothetical protein Antitoxin
BWQ98_RS06025 1136985..1137794 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
BWQ98_RS06030 1137796..1139145 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
BWQ98_RS06035 1139138..1139842 - 705 WP_000722076.1 response regulator transcription factor -
BWQ98_RS06040 1139897..1141072 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T72229 WP_001823540.1 NZ_CP019299:c1136650-1136396 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T72229 NZ_CP019299:c1136650-1136396 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT72229 WP_000208080.1 NZ_CP019299:c1136894-1136652 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT72229 NZ_CP019299:c1136894-1136652 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References