Detailed information of TA system TA072228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 988184..989442
• Replicon: chromosome
• Accession: NZ_CP019299
• Organism: Streptococcus pneumoniae strain HKU1-14

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J2BKK7
• Locus tag: BWQ98_RS05305
• Protein ID: WP_050204890.1
• Coordinates: 988660..989442 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: BWQ98_RS05300
• Protein ID: WP_054388616.1
• Coordinates: 988184..988660 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWQ98_RS05270	983525..983713	+	189	WP_000179769.1	hypothetical protein	-
BWQ98_RS05275	983775..984533	+	759	WP_000262036.1	ATP-grasp domain-containing protein	-
BWQ98_RS05280	984591..985445	+	855	WP_000900015.1	ADP-ribosylglycohydrolase family protein	-
BWQ98_RS05285	985557..986441	+	885	WP_127245051.1	diacylglycerol kinase family lipid kinase	-
BWQ98_RS05290	986604..987308	+	705	WP_101501390.1	alpha amylase N-terminal ig-like domain-containing protein	-
BWQ98_RS05295	987284..987739	+	456	WP_001865186.1	hypothetical protein	-
BWQ98_RS05300	988184..988660	+	477	WP_054388616.1	helix-turn-helix domain-containing protein	Antitoxin
BWQ98_RS05305	988660..989442	+	783	WP_050204890.1	zeta toxin family protein	Toxin
BWQ98_RS05310	989456..991177	+	1722	WP_050091042.1	hypothetical protein	-
BWQ98_RS05315	991164..991706	+	543	WP_050104780.1	hypothetical protein	-
BWQ98_RS05320	991699..994344	+	2646	WP_127245052.1	SMC family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	974262..1001202	26940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30053.06 Da
• Isoelectric Point: 6.9228

>T72228 WP_050204890.1 NZ_CP019299:988660-989442 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVGEERLIESHNKERDNIRE

Nucleotide

• Length: 783 bp

>T72228 NZ_CP019299:988660-989442 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCCTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
AGGGTAGGGGAGGAACGGTTGATAGAATCGCATAACAAAGAAAGAGATAATATTAGGGAGTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18249.63 Da
• Isoelectric Point: 4.2772

>AT72228 WP_054388616.1 NZ_CP019299:988184-988660 [Streptococcus pneumoniae]
MIGKNIQSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT72228 NZ_CP019299:988184-988660 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATACAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4J2BKK7