Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1441875..1442424 Replicon chromosome
Accession NZ_CP019293
Organism Vibrio campbellii strain LMB29

Toxin (Protein)


Gene name parE Uniprot ID A0A2K7SRW8
Locus tag BWP24_RS07315 Protein ID WP_015296889.1
Coordinates 1441875..1442174 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag BWP24_RS07320 Protein ID WP_005442033.1
Coordinates 1442182..1442424 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWP24_RS07250 1437113..1437625 + 513 WP_077200613.1 hypothetical protein -
BWP24_RS07255 1437607..1437732 + 126 WP_086371216.1 DUF3265 domain-containing protein -
BWP24_RS07260 1437764..1438390 + 627 WP_077200615.1 hypothetical protein -
BWP24_RS07265 1438405..1438497 + 93 WP_077200616.1 DUF3265 domain-containing protein -
BWP24_RS07270 1438534..1438959 + 426 WP_077200617.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
BWP24_RS07275 1439107..1439406 + 300 WP_045396921.1 hypothetical protein -
BWP24_RS07280 1439403..1439525 + 123 WP_077200618.1 DUF3265 domain-containing protein -
BWP24_RS07285 1439555..1440139 + 585 WP_038892789.1 hypothetical protein -
BWP24_RS07290 1440136..1440258 + 123 Protein_1327 DUF3265 domain-containing protein -
BWP24_RS07295 1440239..1440856 + 618 WP_077200620.1 YdcF family protein -
BWP24_RS07300 1440847..1440963 + 117 WP_077200621.1 DUF3265 domain-containing protein -
BWP24_RS07305 1441007..1441677 + 671 Protein_1330 hypothetical protein -
BWP24_RS07310 1441698..1441811 + 114 WP_077200622.1 DUF3265 domain-containing protein -
BWP24_RS07315 1441875..1442174 - 300 WP_015296889.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWP24_RS07320 1442182..1442424 - 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BWP24_RS07325 1442499..1442627 + 129 WP_077201264.1 DUF3265 domain-containing protein -
BWP24_RS07330 1442784..1443184 + 401 Protein_1335 hypothetical protein -
BWP24_RS07335 1443224..1443718 + 495 WP_077200623.1 hypothetical protein -
BWP24_RS07340 1443992..1444444 + 453 WP_077200624.1 hypothetical protein -
BWP24_RS07345 1444441..1444929 + 489 WP_077200625.1 hypothetical protein -
BWP24_RS07350 1444916..1445047 + 132 WP_103410848.1 DUF3265 domain-containing protein -
BWP24_RS07355 1445183..1445632 + 450 WP_077200626.1 hypothetical protein -
BWP24_RS07360 1445922..1446062 + 141 WP_170926956.1 DUF3265 domain-containing protein -
BWP24_RS07365 1446173..1446691 + 519 WP_077200627.1 hypothetical protein -
BWP24_RS07370 1446684..1447157 + 474 WP_077200628.1 hypothetical protein -
BWP24_RS07375 1447173..1447293 + 121 Protein_1344 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1369429..1459957 90528
- inside Integron - - 1369961..1451105 81144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11502.11 Da        Isoelectric Point: 9.3224

>T72227 WP_015296889.1 NZ_CP019293:c1442174-1441875 [Vibrio campbellii]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T72227 NZ_CP019293:c1442174-1441875 [Vibrio campbellii]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCACAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT72227 WP_005442033.1 NZ_CP019293:c1442424-1442182 [Vibrio campbellii]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT72227 NZ_CP019293:c1442424-1442182 [Vibrio campbellii]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRW8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References