Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1421220..1421986 Replicon chromosome
Accession NZ_CP019293
Organism Vibrio campbellii strain LMB29

Toxin (Protein)


Gene name - Uniprot ID A0A3Q0L5V0
Locus tag BWP24_RS07050 Protein ID WP_011080392.1
Coordinates 1421220..1421717 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A3N3DV16
Locus tag BWP24_RS07055 Protein ID WP_013571703.1
Coordinates 1421714..1421986 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWP24_RS06975 1416489..1416611 + 123 WP_170926972.1 DUF3265 domain-containing protein -
BWP24_RS06980 1416656..1416964 + 309 WP_077200585.1 hypothetical protein -
BWP24_RS06985 1416982..1417071 + 90 WP_077201258.1 DUF3265 domain-containing protein -
BWP24_RS06990 1417099..1417590 + 492 WP_077200586.1 gamma-glutamylcyclotransferase -
BWP24_RS06995 1417593..1417697 + 105 WP_077200587.1 DUF3265 domain-containing protein -
BWP24_RS07000 1418116..1418244 + 129 WP_077200588.1 DUF3265 domain-containing protein -
BWP24_RS07005 1418252..1418569 - 318 WP_038140554.1 CcdB family protein -
BWP24_RS07010 1418569..1418814 - 246 WP_038140558.1 type II toxin-antitoxin system CcdA family antitoxin -
BWP24_RS07015 1418856..1418981 + 126 WP_077200589.1 DUF3265 domain-containing protein -
BWP24_RS07020 1419018..1419554 + 537 WP_050914845.1 GNAT family N-acetyltransferase -
BWP24_RS07025 1419539..1419661 + 123 WP_077200590.1 DUF3265 domain-containing protein -
BWP24_RS07030 1419698..1420009 + 312 WP_031850888.1 antibiotic biosynthesis monooxygenase -
BWP24_RS07035 1420542..1420634 + 93 WP_170926955.1 DUF3265 domain-containing protein -
BWP24_RS07040 1420661..1421068 + 408 WP_038892264.1 hypothetical protein -
BWP24_RS07045 1421097..1421186 + 90 WP_077201259.1 DUF3265 domain-containing protein -
BWP24_RS07050 1421220..1421717 - 498 WP_011080392.1 GNAT family N-acetyltransferase Toxin
BWP24_RS07055 1421714..1421986 - 273 WP_013571703.1 DUF1778 domain-containing protein Antitoxin
BWP24_RS07060 1422027..1422188 + 162 WP_077201260.1 DUF3265 domain-containing protein -
BWP24_RS07065 1422282..1422701 + 420 WP_077200592.1 hypothetical protein -
BWP24_RS07070 1422713..1422829 + 117 WP_077200593.1 DUF3265 domain-containing protein -
BWP24_RS29430 1422857..1423229 + 373 Protein_1288 hypothetical protein -
BWP24_RS07080 1423233..1423343 + 111 WP_077200594.1 DUF3265 domain-containing protein -
BWP24_RS07085 1423372..1423743 + 372 WP_045381734.1 hypothetical protein -
BWP24_RS07090 1423728..1423859 + 132 WP_077200595.1 DUF3265 domain-containing protein -
BWP24_RS29905 1423979..1424302 + 324 WP_138058874.1 hypothetical protein -
BWP24_RS07100 1424312..1424422 + 111 WP_077200597.1 DUF3265 domain-containing protein -
BWP24_RS07105 1424911..1425042 + 132 WP_077200598.1 DUF3265 domain-containing protein -
BWP24_RS07110 1425073..1425465 + 393 WP_077200599.1 hypothetical protein -
BWP24_RS07115 1425483..1425572 + 90 WP_077201261.1 DUF3265 domain-containing protein -
BWP24_RS07120 1425609..1425920 + 312 WP_005477810.1 antibiotic biosynthesis monooxygenase -
BWP24_RS07125 1425911..1426027 + 117 WP_077200600.1 DUF3265 domain-containing protein -
BWP24_RS07130 1426056..1426409 + 354 WP_015296924.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
BWP24_RS07135 1426370..1426516 + 147 WP_077201262.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1369429..1459957 90528
- inside Integron - - 1369961..1451105 81144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18486.13 Da        Isoelectric Point: 8.0487

>T72226 WP_011080392.1 NZ_CP019293:c1421717-1421220 [Vibrio campbellii]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T72226 NZ_CP019293:c1421717-1421220 [Vibrio campbellii]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACATTTGTTTTGGAAGATGATAACGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9747.28 Da        Isoelectric Point: 8.5960

>AT72226 WP_013571703.1 NZ_CP019293:c1421986-1421714 [Vibrio campbellii]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKIQ

Download         Length: 273 bp

>AT72226 NZ_CP019293:c1421986-1421714 [Vibrio campbellii]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGTATGTCTAGCATCAACTCGTTCGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5V0

Antitoxin

Source ID Structure
AlphaFold DB A0A3N3DV16

References