Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1393145..1393704 Replicon chromosome
Accession NZ_CP019293
Organism Vibrio campbellii strain LMB29

Toxin (Protein)


Gene name relE Uniprot ID A0A2K7SRU8
Locus tag BWP24_RS06685 Protein ID WP_017035198.1
Coordinates 1393145..1393423 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag BWP24_RS06690 Protein ID WP_005398409.1
Coordinates 1393420..1393704 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWP24_RS06630 1388236..1388730 + 495 WP_077200555.1 GNAT family N-acetyltransferase -
BWP24_RS06635 1388759..1388851 + 93 WP_005526494.1 DUF3265 domain-containing protein -
BWP24_RS29395 1389347..1389481 + 135 WP_086371152.1 DUF3265 domain-containing protein -
BWP24_RS06650 1389505..1390239 + 735 WP_082242673.1 hypothetical protein -
BWP24_RS06655 1390236..1390358 + 123 WP_077200558.1 DUF3265 domain-containing protein -
BWP24_RS06660 1390935..1391366 + 432 WP_077200559.1 hypothetical protein -
BWP24_RS06665 1391371..1391481 + 111 WP_077201249.1 DUF3265 domain-containing protein -
BWP24_RS06670 1391602..1392039 + 438 WP_077200560.1 DUF2778 domain-containing protein -
BWP24_RS06675 1392036..1392380 + 345 WP_050918045.1 hypothetical protein -
BWP24_RS06680 1393027..1393116 + 90 WP_077201250.1 DUF3265 domain-containing protein -
BWP24_RS06685 1393145..1393423 - 279 WP_017035198.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BWP24_RS06690 1393420..1393704 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BWP24_RS06695 1393781..1393885 + 105 WP_114144490.1 DUF3265 domain-containing protein -
BWP24_RS06700 1393985..1394263 + 279 WP_077200561.1 hypothetical protein -
BWP24_RS06705 1394283..1394393 + 111 WP_077200562.1 DUF3265 domain-containing protein -
BWP24_RS06710 1394442..1394942 + 501 WP_038892295.1 hypothetical protein -
BWP24_RS06715 1394984..1395073 + 90 WP_077201251.1 DUF3265 domain-containing protein -
BWP24_RS06720 1395100..1395546 + 447 WP_077200563.1 GNAT family N-acetyltransferase -
BWP24_RS06725 1395690..1396436 + 747 WP_077200564.1 hypothetical protein -
BWP24_RS06730 1396433..1396543 + 111 WP_077200565.1 DUF3265 domain-containing protein -
BWP24_RS06740 1396877..1396987 + 111 WP_077201252.1 DUF3265 domain-containing protein -
BWP24_RS06745 1397024..1397356 + 333 WP_009387531.1 hypothetical protein -
BWP24_RS06750 1397353..1397463 + 111 WP_017821978.1 DUF3265 domain-containing protein -
BWP24_RS06755 1397867..1397998 + 132 WP_077200566.1 DUF3265 domain-containing protein -
BWP24_RS06760 1398150..1398566 + 417 WP_077200567.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1369429..1459957 90528
- inside Integron - - 1369961..1451105 81144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T72225 WP_017035198.1 NZ_CP019293:c1393423-1393145 [Vibrio campbellii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T72225 NZ_CP019293:c1393423-1393145 [Vibrio campbellii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGTGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTGCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT72225 WP_005398409.1 NZ_CP019293:c1393704-1393420 [Vibrio campbellii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT72225 NZ_CP019293:c1393704-1393420 [Vibrio campbellii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References