Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1372735..1373282 Replicon chromosome
Accession NZ_CP019293
Organism Vibrio campbellii strain LMB29

Toxin (Protein)


Gene name relE Uniprot ID A0A240EQK2
Locus tag BWP24_RS06480 Protein ID WP_012128216.1
Coordinates 1372980..1373282 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A7MSI1
Locus tag BWP24_RS06475 Protein ID WP_012128217.1
Coordinates 1372735..1372992 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWP24_RS06440 1368243..1368827 + 585 WP_038890023.1 ribosomal protein S5-alanine N-acetyltransferase -
BWP24_RS06445 1368828..1369415 + 588 WP_077200536.1 HD domain-containing protein -
BWP24_RS06450 1369429..1369902 + 474 WP_005434054.1 DUF2947 domain-containing protein -
BWP24_RS06455 1369961..1370923 - 963 WP_045369120.1 integron integrase -
BWP24_RS06460 1371165..1371926 + 762 WP_077200537.1 FRG domain-containing protein -
BWP24_RS06470 1372522..1372653 + 132 WP_077200539.1 DUF3265 domain-containing protein -
BWP24_RS06475 1372735..1372992 + 258 WP_012128217.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BWP24_RS06480 1372980..1373282 + 303 WP_012128216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWP24_RS06485 1373279..1373410 + 132 WP_077201241.1 DUF3265 domain-containing protein -
BWP24_RS06490 1373931..1374020 + 90 WP_075111252.1 DUF3265 domain-containing protein -
BWP24_RS06495 1374066..1374467 + 402 WP_138058870.1 hypothetical protein -
BWP24_RS06500 1374497..1374619 + 123 WP_086371215.1 DUF3265 domain-containing protein -
BWP24_RS06505 1374652..1375212 + 561 WP_077200540.1 hypothetical protein -
BWP24_RS06510 1375528..1375884 + 357 WP_077201243.1 hypothetical protein -
BWP24_RS06515 1375899..1375991 + 93 WP_072600995.1 DUF3265 domain-containing protein -
BWP24_RS06520 1376029..1376469 + 441 WP_077200541.1 hypothetical protein -
BWP24_RS06525 1376466..1376576 + 111 WP_077201244.1 DUF3265 domain-containing protein -
BWP24_RS06530 1376604..1377677 + 1074 WP_077200542.1 hypothetical protein -
BWP24_RS06535 1377692..1377784 + 93 WP_077200543.1 DUF3265 domain-containing protein -
BWP24_RS06540 1377811..1378257 + 447 WP_077200544.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1369429..1459957 90528
- inside Integron - - 1369961..1451105 81144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11699.59 Da        Isoelectric Point: 5.1765

>T72224 WP_012128216.1 NZ_CP019293:1372980-1373282 [Vibrio campbellii]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDSDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T72224 NZ_CP019293:1372980-1373282 [Vibrio campbellii]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCAGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACAGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTACGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9548.06 Da        Isoelectric Point: 7.3177

>AT72224 WP_012128217.1 NZ_CP019293:1372735-1372992 [Vibrio campbellii]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALAGGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT72224 NZ_CP019293:1372735-1372992 [Vibrio campbellii]
ATGAAAGTAGAACTAGTTACATCACTCAAGCGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGGCGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A240EQK2

Antitoxin

Source ID Structure
AlphaFold DB A7MSI1

References