72223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 832920..834496 Replicon chromosome
Accession NZ_CP019292
Organism Vibrio vulnificus strain FORC_053

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FORC53_RS29365 Protein ID WP_118895470.1
Coordinates 833171..834496 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FORC53_RS29360 Protein ID WP_045592353.1
Coordinates 832920..833177 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC53_RS29335 828898..829905 + 1008 WP_118895465.1 hypothetical protein -
FORC53_RS29340 829961..830365 + 405 WP_118895466.1 hypothetical protein -
FORC53_RS29345 830389..830841 - 453 WP_118895467.1 hypothetical protein -
FORC53_RS29350 830831..831703 - 873 WP_118895468.1 Flp pilus assembly complex ATPase component TadA -
FORC53_RS29355 831838..832683 + 846 WP_118895469.1 hypothetical protein -
FORC53_RS29360 832920..833177 + 258 WP_045592353.1 helix-turn-helix domain-containing protein Antitoxin
FORC53_RS29365 833171..834496 + 1326 WP_118895470.1 type II toxin-antitoxin system HipA family toxin Toxin
FORC53_RS29370 834532..835218 - 687 WP_118895471.1 hypothetical protein -
FORC53_RS29375 835333..835776 - 444 WP_118895524.1 EF-hand domain-containing protein -
FORC53_RS29380 835949..836212 - 264 WP_118895472.1 hypothetical protein -
FORC53_RS29385 836246..836650 - 405 WP_020330727.1 hypothetical protein -
FORC53_RS29390 836749..837411 - 663 WP_085762237.1 DUF262 domain-containing protein -
FORC53_RS29395 837466..837750 - 285 WP_118895473.1 hypothetical protein -
FORC53_RS29400 837850..838446 - 597 WP_118895474.1 hypothetical protein -
FORC53_RS29405 838646..838870 + 225 WP_021485441.1 hypothetical protein -
FORC53_RS29410 838879..839187 + 309 WP_198434351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49424.72 Da        Isoelectric Point: 6.7016

>T72223 WP_118895470.1 NZ_CP019292:833171-834496 [Vibrio vulnificus]
MVKQLRVLMNGESVGVFTKEPSGAHSFQYGEEWLNSSKSRPISLSIPLRREPYRGDIVINFFDNLLPDNPQVRDRIVARY
GAKTKQPFDLLEKIGRDSVGAITLIPEGEPIPEFKGIRATELSLIKLEQVLNSYADNIPLGMVDGNDDFRISIAGAQEKT
ALLKLDERWFIPQGATPTTHIIKLPIGEIRTQDSVLDLTASVDNELVCMRLSEAFGLPTASCDVIRAGGVRALAVERFDR
RFSQLKDWIVRLPQEDFCQVSGMPSASKYESDGGIGIEGIMDHLLGSEVPQEDRRTFMRSQVLFYLLAAIDGHSKNFSLF
IEPHGKYRLTPLYDIMSAYPLMGGRGLHERKIKLAMGLKASSGYKRKWHQIQPRHFIGTARLVKYSSDSMRDILDEFIAD
CGQVIDLVGNNLPDDINENVRDKIFEGLTKSVKKLSLGLND

Download         Length: 1326 bp

>T72223 NZ_CP019292:833171-834496 [Vibrio vulnificus]
ATGGTAAAGCAATTACGCGTGTTAATGAATGGTGAGTCAGTAGGGGTGTTCACTAAAGAACCTAGTGGTGCTCATAGCTT
TCAATATGGCGAAGAATGGTTAAACTCTAGTAAATCTCGCCCGATATCATTATCAATCCCCCTTCGCCGTGAGCCGTACA
GGGGTGATATAGTGATTAACTTTTTCGACAACCTGCTTCCAGATAACCCTCAGGTTCGAGACCGAATCGTTGCTCGATAC
GGTGCCAAAACAAAACAGCCATTCGATCTTTTGGAAAAGATAGGGCGCGATAGTGTTGGGGCAATCACCCTTATTCCTGA
AGGCGAACCGATTCCAGAATTTAAGGGGATAAGAGCTACTGAGCTTTCCCTTATAAAGCTTGAACAAGTTCTTAATTCCT
ATGCAGACAATATCCCTTTAGGCATGGTTGATGGAAATGATGATTTCAGGATCTCCATTGCTGGCGCTCAAGAGAAAACT
GCCTTGTTGAAGTTGGATGAGCGTTGGTTTATACCGCAAGGTGCAACTCCAACCACACACATTATAAAACTTCCGATTGG
TGAAATACGGACGCAGGACAGCGTTTTAGACCTAACAGCCAGTGTTGATAATGAACTCGTGTGTATGAGGCTTTCTGAAG
CGTTTGGACTGCCTACAGCCTCTTGTGACGTTATTAGGGCTGGTGGAGTAAGGGCGCTTGCCGTTGAGCGTTTCGATAGA
CGATTCTCACAACTAAAAGATTGGATTGTACGCTTGCCTCAAGAAGACTTTTGCCAAGTGTCTGGTATGCCATCGGCAAG
CAAATATGAATCAGATGGTGGTATCGGTATTGAAGGAATAATGGATCATCTTCTTGGCTCAGAGGTTCCTCAGGAAGACA
GGAGAACCTTTATGCGTTCTCAAGTTCTGTTCTATTTACTTGCTGCAATAGATGGTCACTCAAAAAACTTTTCGCTATTC
ATAGAGCCTCATGGTAAGTACCGATTAACGCCTTTGTACGACATTATGTCAGCCTACCCTCTTATGGGTGGTAGAGGGCT
TCATGAAAGAAAAATCAAGCTGGCAATGGGACTAAAGGCAAGTAGCGGATACAAACGTAAGTGGCATCAGATACAGCCTA
GACATTTTATCGGTACAGCGAGGCTAGTGAAGTATTCATCGGACTCTATGAGAGATATTCTGGATGAGTTTATTGCTGAT
TGTGGACAGGTTATCGATCTAGTTGGGAACAATCTTCCAGATGATATCAATGAGAATGTTCGGGATAAAATCTTTGAGGG
ATTAACAAAATCAGTGAAAAAACTGAGTCTTGGTCTAAATGATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9676.04 Da        Isoelectric Point: 8.7273

>AT72223 WP_045592353.1 NZ_CP019292:832920-833177 [Vibrio vulnificus]
MLITSSRQLAIHLRDERKSRKLSQAKVADPVGIKQDTVSKFEVNPETTSIQTLFRILSSLNLEMHIVPKGQSIDPKTDNE
SDEKW

Download         Length: 258 bp

>AT72223 NZ_CP019292:832920-833177 [Vibrio vulnificus]
ATGTTGATAACATCATCCAGGCAGTTAGCAATACATCTTCGTGATGAAAGAAAAAGCAGGAAGCTATCTCAAGCAAAAGT
TGCTGATCCAGTAGGGATAAAACAAGACACGGTTTCTAAGTTTGAGGTTAATCCTGAAACCACCAGCATTCAGACGCTAT
TTCGAATCTTATCATCGTTAAATTTGGAAATGCATATTGTGCCGAAAGGTCAAAGCATTGACCCAAAAACTGATAATGAG
AGTGATGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References