72222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 798710..800057 Replicon chromosome
Accession NZ_CP019291
Organism Vibrio vulnificus strain FORC_053

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag FORC53_RS19580 Protein ID WP_015727856.1
Coordinates 799116..800057 (+) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A3Q0KXE1
Locus tag FORC53_RS19575 Protein ID WP_011081161.1
Coordinates 798710..799114 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC53_RS19555 793905..794363 + 459 WP_045598334.1 hypothetical protein -
FORC53_RS19560 794553..795299 + 747 WP_198434322.1 carbon-nitrogen hydrolase family protein -
FORC53_RS29945 795331..795480 - 150 WP_157401215.1 hypothetical protein -
FORC53_RS19565 795799..796563 + 765 WP_118894273.1 nucleotidyltransferase domain-containing protein -
FORC53_RS19570 796616..798376 - 1761 WP_118894274.1 ABC transporter ATP-binding protein/permease -
FORC53_RS19575 798710..799114 + 405 WP_011081161.1 hypothetical protein Antitoxin
FORC53_RS19580 799116..800057 + 942 WP_015727856.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FORC53_RS19585 800444..802030 + 1587 WP_045622347.1 AAA family ATPase -
FORC53_RS19590 802015..803046 + 1032 WP_118894275.1 DNA helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 791472..806596 15124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 36057.46 Da        Isoelectric Point: 5.3076

>T72222 WP_015727856.1 NZ_CP019291:799116-800057 [Vibrio vulnificus]
MNALKQQFLEVSDALELGNPAIIEKDFWVVALLAELAKVSPEYHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRAKKKGVRKAWVNEIEQAITHSERFTVETRSVRDEYRYVEFELRYPQQFSQVPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPHEVSSFDCVSVYATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCITKLTMSELNSIDGLFKAVL
EEDIARFGNQHAEFVANPKQELQLGLKELEENPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T72222 NZ_CP019291:799116-800057 [Vibrio vulnificus]
ATGAACGCACTAAAACAACAATTTCTTGAGGTTTCCGACGCGCTTGAGCTCGGAAATCCTGCCATCATTGAAAAAGATTT
CTGGGTCGTCGCCTTACTTGCCGAGCTAGCAAAAGTTTCTCCTGAATATCATCAAATGGTCTTTTCCGGCGGCACGGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCAAGCGTTTGATGAA
CTGAGTCGAGCAAAAAAGAAAGGCGTTAGAAAGGCATGGGTTAACGAGATTGAACAGGCGATCACTCATTCAGAACGATT
TACCGTTGAAACGCGATCTGTGCGAGATGAGTACCGTTACGTTGAGTTTGAACTCAGATATCCGCAACAGTTTAGTCAAG
TTCCCTGTCTTCGTCCCATCATTAAGTTAGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCATTGGTTGCAGAGTTGTACCAACAACCGCACGAAGTGAGTTCATTTGATTGCGTCTCTGTCTATGCCACATTGGTTGA
AAAAATCATTTCGATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAAGCGATGATGTTGCTCTAGTTCGCC
ATATCTACGATGTGCATTGCATAACAAAGCTCACAATGTCTGAACTCAACTCGATTGACGGCCTATTCAAAGCGGTCTTG
GAAGAAGATATTGCCCGCTTTGGCAATCAACATGCAGAGTTTGTTGCCAACCCTAAACAAGAGCTACAACTTGGCCTCAA
AGAGCTTGAGGAAAATCCCATTTTCCGCCAACGTTTTCAGGACTTTGTCACACCAATGGTGTTTAACACTGAGCCCCATG
ATTTTGATACCTGCTTTGCCTCATTCAAGCGAATTGCAGCGTCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15175.47 Da        Isoelectric Point: 10.6526

>AT72222 WP_011081161.1 NZ_CP019291:798710-799114 [Vibrio vulnificus]
MTAVDRIYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALVRE
ILKMKGVDFEMDSLSQQSLSGASTQIPSSVHYSWNPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT72222 NZ_CP019291:798710-799114 [Vibrio vulnificus]
ATGACAGCAGTAGACCGCATTTATCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGACGGATT
TGCAAGTTACGACCAAATAGGTCGGGCATTGAGGCAGCTTGTACAGCAAGGGGAGCTAATGAAGCTTGGCTATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGTAAGCCTATGCCTACCAATCCAGGTGGTACCGATGCTCTTGTGCGTGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAAATGGATAGTCTATCGCAACAAAGTCTTTCAGGTGCGAGTACCCAAATTCC
ATCCTCTGTTCACTATTCATGGAACCCAAAACAGTTTAATCGCAAACTGGTGGTTGGTAGCCGTGTGCTGAACTTGCCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0KXE1

References