72220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2584352..2586180 Replicon chromosome
Accession NZ_CP019290
Organism Vibrio vulnificus strain FORC_053

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FORC53_RS12960 Protein ID WP_043877077.1
Coordinates 2584352..2585713 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FORC53_RS12965 Protein ID WP_118893920.1
Coordinates 2585698..2586180 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC53_RS12930 2579778..2581442 + 1665 WP_108694289.1 DNA repair protein RecN -
FORC53_RS12935 2581621..2581980 + 360 WP_011078463.1 outer membrane protein assembly factor BamE -
FORC53_RS12940 2582076..2582429 - 354 WP_039552946.1 RnfH family protein -
FORC53_RS12945 2582426..2582857 - 432 WP_026050324.1 ubiquinone-binding protein -
FORC53_RS12950 2582973..2583458 + 486 WP_011078466.1 SsrA-binding protein SmpB -
FORC53_RS12960 2584352..2585713 + 1362 WP_043877077.1 type II toxin-antitoxin system HipA family toxin Toxin
FORC53_RS12965 2585698..2586180 + 483 WP_118893920.1 helix-turn-helix domain-containing protein Antitoxin
FORC53_RS12970 2586615..2588357 - 1743 WP_045598198.1 lysophospholipid acyltransferase family protein -
FORC53_RS12975 2588400..2588837 - 438 WP_011078502.1 YHS domain-containing protein -
FORC53_RS12980 2588852..2589607 - 756 WP_118893921.1 NRDE family protein -
FORC53_RS12985 2589609..2590163 - 555 WP_011078504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51446.22 Da        Isoelectric Point: 4.8137

>T72220 WP_043877077.1 NZ_CP019290:2584352-2585713 [Vibrio vulnificus]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFNDMGKPGWLKFLDDIM
PSGASRRYWVRYLDIEDLSSDEQDYVLLKFGTMSPVGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYALQRGAAA
GGATGAGGEAPKLILRCGLDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFIGIADTLSDLV
PKEVLLQELEITASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T72220 NZ_CP019290:2584352-2585713 [Vibrio vulnificus]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAAGTGAATGGATAGACATTGGTATCATCTCATTCCCAAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTAATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGCGGCGCTAGTAGACGGTACTGGGTCAGATATCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTGTTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACTGCAAAGGGGCGCAGCCGCG
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTCTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCAGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTAATGAGCA
GCAAATCGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCATTAGAGGTTGGCGGAACTTACGACTTCATCGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAGGTGTTATTACAAGAGCTAGAGATTACTGCAAGTAAATGCATTGACTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17562.08 Da        Isoelectric Point: 10.8446

>AT72220 WP_118893920.1 NZ_CP019290:2585698-2586180 [Vibrio vulnificus]
MGATMNKPNNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT72220 NZ_CP019290:2585698-2586180 [Vibrio vulnificus]
ATGGGGGCTACTATGAATAAGCCAAACAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AGCCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References