72219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1568433..1568971 Replicon chromosome
Accession NZ_CP019290
Organism Vibrio vulnificus strain FORC_053

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC53_RS08260 Protein ID WP_001247271.1
Coordinates 1568433..1568732 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag FORC53_RS08265 Protein ID WP_011080384.1
Coordinates 1568729..1568971 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC53_RS08190 1563555..1563698 + 144 WP_072612500.1 DUF3265 domain-containing protein -
FORC53_RS08195 1564032..1564154 + 123 WP_072612501.1 DUF3265 domain-containing protein -
FORC53_RS08200 1564247..1564513 + 267 WP_013571723.1 hypothetical protein -
FORC53_RS08205 1564675..1564986 + 312 WP_044023869.1 antibiotic biosynthesis monooxygenase -
FORC53_RS08210 1564977..1565111 + 135 WP_103196841.1 DUF3265 domain-containing protein -
FORC53_RS08215 1565455..1565577 + 123 WP_118894107.1 DUF3265 domain-containing protein -
FORC53_RS08220 1565686..1566105 + 420 WP_103193391.1 GNAT family N-acetyltransferase -
FORC53_RS08225 1566098..1566229 + 132 WP_118893694.1 DUF3265 domain-containing protein -
FORC53_RS08230 1566572..1566733 + 162 WP_118893695.1 DUF3265 domain-containing protein -
FORC53_RS08235 1566717..1567223 + 507 WP_013571676.1 GNAT family N-acetyltransferase -
FORC53_RS08240 1567233..1567397 + 165 WP_102970004.1 DUF3265 domain-containing protein -
FORC53_RS08245 1567325..1567687 + 363 WP_103193535.1 DUF4144 domain-containing protein -
FORC53_RS08250 1567731..1567820 + 90 Protein_1514 DUF3265 domain-containing protein -
FORC53_RS29850 1567846..1568319 + 474 WP_044023871.1 hypothetical protein -
FORC53_RS08255 1568267..1568425 + 159 WP_072612492.1 DUF3265 domain-containing protein -
FORC53_RS08260 1568433..1568732 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC53_RS08265 1568729..1568971 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC53_RS08270 1569005..1569157 + 153 WP_072612493.1 DUF3265 domain-containing protein -
FORC53_RS08275 1569177..1569479 + 303 WP_118893581.1 hypothetical protein -
FORC53_RS08280 1569517..1569585 + 69 WP_080252462.1 DUF3265 domain-containing protein -
FORC53_RS08285 1569724..1569945 + 222 WP_000076907.1 VF530 family protein -
FORC53_RS08290 1569956..1570084 + 129 WP_080557521.1 DUF3265 domain-containing protein -
FORC53_RS08295 1570436..1570579 + 144 WP_072612495.1 DUF3265 domain-containing protein -
FORC53_RS08300 1570576..1570878 + 303 WP_011080371.1 hypothetical protein -
FORC53_RS08305 1571350..1571472 + 123 WP_081946703.1 DUF3265 domain-containing protein -
FORC53_RS08310 1571490..1571921 + 432 WP_118893696.1 hypothetical protein -
FORC53_RS08320 1572382..1572525 + 144 Protein_1528 DUF3265 domain-containing protein -
FORC53_RS08325 1572554..1573315 + 762 WP_065090422.1 hypothetical protein -
FORC53_RS08330 1573330..1573422 + 93 WP_108678077.1 DUF3265 domain-containing protein -
FORC53_RS08335 1573456..1573962 + 507 WP_043920996.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 / VP1611 1182668..1712415 529747
- inside Integron - - 1430179..1576433 146254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T72219 WP_001247271.1 NZ_CP019290:c1568732-1568433 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T72219 NZ_CP019290:c1568732-1568433 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAACCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT72219 WP_011080384.1 NZ_CP019290:c1568971-1568729 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT72219 NZ_CP019290:c1568971-1568729 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References