72218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1554141..1554688 Replicon chromosome
Accession NZ_CP019290
Organism Vibrio vulnificus strain FORC_053

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y0S5Y1
Locus tag FORC53_RS08080 Protein ID WP_025796191.1
Coordinates 1554386..1554688 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag FORC53_RS08075 Protein ID WP_005448240.1
Coordinates 1554141..1554398 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC53_RS08010 1549420..1549542 + 123 WP_085761039.1 DUF3265 domain-containing protein -
FORC53_RS08015 1549572..1549922 + 351 WP_025502456.1 RidA family protein -
FORC53_RS08020 1550077..1550412 + 336 WP_044023852.1 hypothetical protein -
FORC53_RS08025 1550393..1550530 + 138 Protein_1472 DUF3265 domain-containing protein -
FORC53_RS08030 1550551..1550889 + 339 WP_118893685.1 aldehyde-activating protein -
FORC53_RS08035 1551038..1551544 + 507 WP_039555194.1 AAA family ATPase -
FORC53_RS08040 1551553..1551693 + 141 WP_118894103.1 DUF3265 domain-containing protein -
FORC53_RS08045 1551690..1551938 + 249 WP_023622767.1 hypothetical protein -
FORC53_RS08050 1551935..1552066 + 132 WP_118894104.1 DUF3265 domain-containing protein -
FORC53_RS08055 1552084..1552737 + 654 WP_045596301.1 hypothetical protein -
FORC53_RS08060 1553207..1553362 + 156 WP_118893686.1 DUF3265 domain-containing protein -
FORC53_RS08065 1553355..1553951 + 597 WP_045623461.1 class I SAM-dependent methyltransferase -
FORC53_RS29845 1553948..1554070 + 123 Protein_1481 DUF3265 domain-containing protein -
FORC53_RS08075 1554141..1554398 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC53_RS08080 1554386..1554688 + 303 WP_025796191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC53_RS08085 1554727..1554816 + 90 WP_118894106.1 DUF3265 domain-containing protein -
FORC53_RS08090 1554843..1555517 + 675 WP_118893687.1 hypothetical protein -
FORC53_RS08095 1555653..1555988 + 336 WP_060531572.1 hypothetical protein -
FORC53_RS08105 1556124..1556486 - 363 WP_080608854.1 glyoxalase -
FORC53_RS08110 1556570..1556713 + 144 WP_118893688.1 DUF3265 domain-containing protein -
FORC53_RS08125 1557481..1557621 + 141 Protein_1489 DUF3265 domain-containing protein -
FORC53_RS08130 1557621..1558082 + 462 WP_043921024.1 GNAT family N-acetyltransferase -
FORC53_RS08135 1558079..1558189 + 111 Protein_1491 DUF3265 domain-containing protein -
FORC53_RS08140 1558531..1558656 + 126 WP_079324899.1 DUF3265 domain-containing protein -
FORC53_RS08145 1558757..1559680 + 924 WP_118893690.1 zinc dependent phospholipase C family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 / VP1611 1182668..1712415 529747
- inside Integron - - 1430179..1576433 146254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11655.54 Da        Isoelectric Point: 5.1765

>T72218 WP_025796191.1 NZ_CP019290:1554386-1554688 [Vibrio vulnificus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T72218 NZ_CP019290:1554386-1554688 [Vibrio vulnificus]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATATATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCGGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT72218 WP_005448240.1 NZ_CP019290:1554141-1554398 [Vibrio vulnificus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT72218 NZ_CP019290:1554141-1554398 [Vibrio vulnificus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCATGACACTAAAGAACCCGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTCGTTGACGTTGATGACTATGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCAAGAGGTGAGCGTGCGTTAGCTGACGGTAAAGTGGTAAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y0S5Y1

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References