Detailed information of TA system TA072217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1511679..1512224
• Replicon: chromosome
• Accession: NZ_CP019290
• Organism: Vibrio vulnificus strain FORC_053

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FORC53_RS07580
• Protein ID: WP_118893650.1
• Coordinates: 1511679..1511975 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FORC53_RS07585
• Protein ID: WP_118893651.1
• Coordinates: 1511982..1512224 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC53_RS07535	1507274..1507350	+	77	Protein_1380	DUF3265 domain-containing protein	-
FORC53_RS07540	1507377..1508195	+	819	WP_118893645.1	hypothetical protein	-
FORC53_RS07545	1508347..1508619	+	273	WP_025523449.1	hypothetical protein	-
FORC53_RS07550	1509092..1509214	+	123	WP_072611734.1	DUF3265 domain-containing protein	-
FORC53_RS07555	1509231..1509698	+	468	WP_118893646.1	NUDIX domain-containing protein	-
FORC53_RS07560	1509721..1509813	+	93	WP_083135209.1	DUF3265 domain-containing protein	-
FORC53_RS07565	1509893..1510450	+	558	WP_118893648.1	hypothetical protein	-
FORC53_RS07575	1511506..1511628	+	123	WP_118894091.1	DUF3265 domain-containing protein	-
FORC53_RS07580	1511679..1511975	-	297	WP_118893650.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC53_RS07585	1511982..1512224	-	243	WP_118893651.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC53_RS07590	1512464..1512913	+	450	WP_043921029.1	hypothetical protein	-
FORC53_RS07595	1512928..1513062	+	135	WP_118893652.1	DUF3265 domain-containing protein	-
FORC53_RS07600	1513397..1513519	+	123	WP_118894092.1	DUF3265 domain-containing protein	-
FORC53_RS07605	1513553..1513861	+	309	WP_118893653.1	hypothetical protein	-
FORC53_RS07610	1513879..1513968	+	90	Protein_1394	DUF3265 domain-containing protein	-
FORC53_RS07615	1514002..1514451	+	450	WP_118893654.1	hypothetical protein	-
FORC53_RS07620	1514636..1515415	-	780	WP_118893655.1	hypothetical protein	-
FORC53_RS07625	1515659..1516075	+	417	WP_011150394.1	hypothetical protein	-
FORC53_RS07630	1516090..1516182	+	93	WP_079751666.1	DUF3265 domain-containing protein	-
FORC53_RS07635	1516230..1516598	+	369	WP_011080402.1	VOC family protein	-
FORC53_RS07640	1516613..1516756	+	144	WP_118893656.1	DUF3265 domain-containing protein	-
FORC53_RS07645	1516766..1517191	+	426	WP_118893657.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1 / VP1611	1182668..1712415	529747
	-	inside	Integron	-	-	1430179..1576433	146254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11260.92 Da
• Isoelectric Point: 9.5676

>T72217 WP_118893650.1 NZ_CP019290:c1511975-1511679 [Vibrio vulnificus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWNNYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNYL

Nucleotide

• Length: 297 bp

>T72217 NZ_CP019290:c1511975-1511679 [Vibrio vulnificus]
ATGCAAAAGAACAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGCTATACCGTCAACAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAACTGGGTTTCAAATGCTTGCCGACAATCCAGCCGTAGGTC
GCAGTTGTGATGAGATTTATCCAAGCGGTTTCTATTTTCCGGTAGGAAAACACACGGCTTACTTTACAAAAGAAGACGGT
TTTATCTTAGTTGTGGCTGTACTTGGTCAATCACAACTCCCCCAAAACTACTTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8947.14 Da
• Isoelectric Point: 4.7914

>AT72217 WP_118893651.1 NZ_CP019290:c1512224-1511982 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKQDLAQGNVVDGEDFLSTL

Nucleotide

• Length: 243 bp

>AT72217 NZ_CP019290:c1512224-1511982 [Vibrio vulnificus]
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGCTGCTTCTAAGCGCCCAACGTGAACCAGTAAAGAT
TAGCAAAAACAGTAAAGATGCCGTAGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAGCTGATTACC
TTAAACATTGTTTCGAGTCAGCTAAACAAGACTTAGCACAAGGCAATGTAGTTGATGGTGAAGATTTCCTAAGCACCTTG
TAA