Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1013151..1014712 Replicon chromosome
Accession NZ_CP019290
Organism Vibrio vulnificus strain FORC_053

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FORC53_RS04865 Protein ID WP_025637698.1
Coordinates 1013384..1014712 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FORC53_RS04860 Protein ID WP_017788886.1
Coordinates 1013151..1013390 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC53_RS04835 1008189..1009372 + 1184 Protein_873 hypothetical protein -
FORC53_RS04840 1010385..1011131 + 747 WP_118893479.1 hypothetical protein -
FORC53_RS04845 1011285..1011914 + 630 WP_025637703.1 hypothetical protein -
FORC53_RS04850 1011956..1012360 + 405 WP_130193433.1 hypothetical protein -
FORC53_RS04860 1013151..1013390 + 240 WP_017788886.1 helix-turn-helix domain-containing protein Antitoxin
FORC53_RS04865 1013384..1014712 + 1329 WP_025637698.1 type II toxin-antitoxin system HipA family toxin Toxin
FORC53_RS04870 1014904..1016226 - 1323 WP_118893481.1 site-specific integrase -
FORC53_RS04875 1017042..1017677 + 636 WP_072616074.1 magnesium transporter -
FORC53_RS04880 1017815..1018867 + 1053 WP_118893482.1 GGDEF domain-containing protein -
FORC53_RS04885 1019068..1019532 + 465 WP_118893483.1 DUF2846 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 990652..1016226 25574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-55)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49590.95 Da        Isoelectric Point: 8.8662

>T72216 WP_025637698.1 NZ_CP019290:1013384-1014712 [Vibrio vulnificus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSDWISAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSEKELVRILKGYMEGAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIISQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGLEESIGILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
SAAMEVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Download         Length: 1329 bp

>T72216 NZ_CP019290:1013384-1014712 [Vibrio vulnificus]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGACTGGATTTCAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAATCAGCAGATACGAGATAGAATAGCCGCTCGCTAT
AAAGCAGATACTAAACAGCCATTTGACCTACTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGCTAGTTCCAGA
GGGCTTTGATGTAGATGATCATCGAGTTATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGGCGCTCCTCTGGGAATGTTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTATTCCACGATGGAAGATGGATGTTGCCACAGGGAATGACTCCAACTACGCATATTATCAAGTTGCCAATAGG
CGAAATTATTTCTCAGAACAATGTTATTGATTTGTCTGCAAGTGTCGATAATGAGTTGATTTGTATGAGACTAGCAAAGG
CGTTCGGTATTCAGACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCCGTTGAGCGATTTGACCGA
AAATTATCTTCTGACAACAGCTATTATTTACGCTTGCCCCACGAGGACTTTTGCCAGGCAAAAGGAATTCCATCAGCTAG
AAAGTATGAAATCGACGGTGGTATTGGGTTAGAAGAATCTATTGGTATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATTTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGTCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTCGATGAGTTTGAA
TCGGCGGCAATGGAGGTGATTGATTCTGTCGGAAACTCTCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAAATTCAATTGACAAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.96 Da        Isoelectric Point: 7.2036

>AT72216 WP_017788886.1 NZ_CP019290:1013151-1013390 [Vibrio vulnificus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Download         Length: 240 bp

>AT72216 NZ_CP019290:1013151-1013390 [Vibrio vulnificus]
ATGCTAGTTAACACACCGACAGCCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAACGGCCTAAAGCAAACAGATCT
TGGCCTGCGGCAAGCAACGGTATCAAATTTTGAAAGCAACCCTGAAAAATCTACGATAGAAACATTATTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCTAAAGGCAAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References