Detailed information of TA system TA072216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1013151..1014712
• Replicon: chromosome
• Accession: NZ_CP019290
• Organism: Vibrio vulnificus strain FORC_053

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FORC53_RS04865
• Protein ID: WP_025637698.1
• Coordinates: 1013384..1014712 (+)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FORC53_RS04860
• Protein ID: WP_017788886.1
• Coordinates: 1013151..1013390 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC53_RS04835	1008189..1009372	+	1184	Protein_873	hypothetical protein	-
FORC53_RS04840	1010385..1011131	+	747	WP_118893479.1	hypothetical protein	-
FORC53_RS04845	1011285..1011914	+	630	WP_025637703.1	hypothetical protein	-
FORC53_RS04850	1011956..1012360	+	405	WP_130193433.1	hypothetical protein	-
FORC53_RS04860	1013151..1013390	+	240	WP_017788886.1	helix-turn-helix domain-containing protein	Antitoxin
FORC53_RS04865	1013384..1014712	+	1329	WP_025637698.1	type II toxin-antitoxin system HipA family toxin	Toxin
FORC53_RS04870	1014904..1016226	-	1323	WP_118893481.1	site-specific integrase	-
FORC53_RS04875	1017042..1017677	+	636	WP_072616074.1	magnesium transporter	-
FORC53_RS04880	1017815..1018867	+	1053	WP_118893482.1	GGDEF domain-containing protein	-
FORC53_RS04885	1019068..1019532	+	465	WP_118893483.1	DUF2846 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	990652..1016226	25574

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49590.95 Da
• Isoelectric Point: 8.8662

>T72216 WP_025637698.1 NZ_CP019290:1013384-1014712 [Vibrio vulnificus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSDWISAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSEKELVRILKGYMEGAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIISQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGLEESIGILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
SAAMEVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T72216 NZ_CP019290:1013384-1014712 [Vibrio vulnificus]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGACTGGATTTCAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAATCAGCAGATACGAGATAGAATAGCCGCTCGCTAT
AAAGCAGATACTAAACAGCCATTTGACCTACTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGCTAGTTCCAGA
GGGCTTTGATGTAGATGATCATCGAGTTATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGGCGCTCCTCTGGGAATGTTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTATTCCACGATGGAAGATGGATGTTGCCACAGGGAATGACTCCAACTACGCATATTATCAAGTTGCCAATAGG
CGAAATTATTTCTCAGAACAATGTTATTGATTTGTCTGCAAGTGTCGATAATGAGTTGATTTGTATGAGACTAGCAAAGG
CGTTCGGTATTCAGACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCCGTTGAGCGATTTGACCGA
AAATTATCTTCTGACAACAGCTATTATTTACGCTTGCCCCACGAGGACTTTTGCCAGGCAAAAGGAATTCCATCAGCTAG
AAAGTATGAAATCGACGGTGGTATTGGGTTAGAAGAATCTATTGGTATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATTTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGTCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTCGATGAGTTTGAA
TCGGCGGCAATGGAGGTGATTGATTCTGTCGGAAACTCTCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAAATTCAATTGACAAAAAAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.96 Da
• Isoelectric Point: 7.2036

>AT72216 WP_017788886.1 NZ_CP019290:1013151-1013390 [Vibrio vulnificus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Nucleotide

• Length: 240 bp

>AT72216 NZ_CP019290:1013151-1013390 [Vibrio vulnificus]
ATGCTAGTTAACACACCGACAGCCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAACGGCCTAAAGCAAACAGATCT
TGGCCTGCGGCAAGCAACGGTATCAAATTTTGAAAGCAACCCTGAAAAATCTACGATAGAAACATTATTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCTAAAGGCAAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA