Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 33540..34062 Replicon plasmid p13P484A-4
Accession NZ_CP019284
Organism Escherichia coli strain 13P484A

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag BWI90_RS27000 Protein ID WP_000220561.1
Coordinates 33781..34062 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag BWI90_RS26995 Protein ID WP_000121743.1
Coordinates 33540..33791 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI90_RS26970 28779..29639 + 861 WP_063122221.1 hypothetical protein -
BWI90_RS26975 29660..30085 - 426 WP_001694624.1 hypothetical protein -
BWI90_RS26980 30153..30599 - 447 WP_001074384.1 hypothetical protein -
BWI90_RS26985 30603..31445 - 843 WP_000435064.1 replication initiation protein -
BWI90_RS26990 31466..32305 - 840 WP_001352874.1 replication initiation protein -
BWI90_RS26995 33540..33791 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
BWI90_RS27000 33781..34062 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWI90_RS27005 34412..34927 + 516 WP_001025387.1 J domain-containing protein -
BWI90_RS27010 35001..35549 + 549 WP_001178641.1 hypothetical protein -
BWI90_RS27015 35615..35827 + 213 WP_001446884.1 hypothetical protein -
BWI90_RS27020 35817..36059 + 243 WP_000008708.1 hypothetical protein -
BWI90_RS27025 36192..36896 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
BWI90_RS27035 36951..37403 - 453 Protein_47 IS4 family transposase -
BWI90_RS27045 37546..38406 + 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -
BWI90_RS27050 38419..38961 + 543 WP_148119865.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid catA2 / aac(3)-IId / blaTEM-1B / aph(3'')-Ib / aph(6)-Id - 1..93578 93578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T72215 WP_000220561.1 NZ_CP019284:33781-34062 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T72215 NZ_CP019284:33781-34062 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT72215 WP_000121743.1 NZ_CP019284:33540-33791 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT72215 NZ_CP019284:33540-33791 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References