Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 139734..140359 Replicon plasmid p13P484A-2
Accession NZ_CP019282
Organism Escherichia coli strain 13P484A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BWI90_RS26005 Protein ID WP_000911313.1
Coordinates 139734..140132 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag BWI90_RS26010 Protein ID WP_000450520.1
Coordinates 140132..140359 (-) Length 76 a.a.

Genomic Context

BWI90_RS25990BWI90_RS25995BWI90_RS26000BWI90_RS26005BWI90_RS26010
Location: 136059..136556 (498 bp)
Type: Others
Protein ID: WP_000605857.1
Location: 136588..137319 (732 bp)
Type: Others
Protein ID: WP_023565183.1
Location: 137572..139725 (2154 bp)
Type: Others
Protein ID: WP_000009324.1
Location: 139734..140132 (399 bp)
Type: Toxin
Protein ID: WP_000911313.1
Location: 140132..140359 (228 bp)
Type: Antitoxin
Protein ID: WP_000450520.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BWI90_RS25990136059..136556+498WP_000605857.1entry exclusion protein-
BWI90_RS25995136588..137319+732WP_023565183.1complement resistance protein TraT-
BWI90_RS26000137572..139725+2154WP_000009324.1type IV conjugative transfer system coupling protein TraD-
BWI90_RS26005139734..140132-399WP_000911313.1tRNA(fMet)-specific endonuclease VapCToxin
BWI90_RS26010140132..140359-228WP_000450520.1toxin-antitoxin system antitoxin VapBAntitoxin

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidblaTEM-1B / blaCTX-M-15 / fosA3 / mph(A) / qacE / aadA2 / dfrA12 / oqxB / oqxA / tet(A) / sitABCDiroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA1..149520149520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T72214 WP_000911313.1 NZ_CP019282:c140132-139734 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

>T72214 NZ_CP019282:c140132-139734 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT72214 WP_000450520.1 NZ_CP019282:c140359-140132 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT72214 NZ_CP019282:c140359-140132 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBV0VCB2

References