Detailed information of TA system TA072108

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 734669..735516
• Replicon: chromosome
• Accession: NZ_CP019271
• Organism: Escherichia coli strain 13P460A

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: BWI88_RS03765
• Protein ID: WP_112044915.1
• Coordinates: 734669..735058 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: BWI88_RS03770
• Protein ID: WP_112044916.1
• Coordinates: 735148..735516 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI88_RS03740	730468..731316	-	849	WP_112044913.1	DUF4942 domain-containing protein	-
BWI88_RS03745	731401..731598	-	198	WP_000839267.1	DUF957 domain-containing protein	-
BWI88_RS26715	731610..731765	-	156	WP_199776868.1	hypothetical protein	-
BWI88_RS03750	731933..733474	+	1542	WP_001298859.1	IS21-like element ISEc12 family transposase	-
BWI88_RS03755	733489..734235	+	747	WP_001016257.1	IS21-like element ISEc12 family helper ATPase IstB	-
BWI88_RS03760	734325..734684	-	360	Protein_680	hypothetical protein	-
BWI88_RS03765	734669..735058	-	390	WP_112044915.1	type IV toxin-antitoxin system toxin CbtA	Toxin
BWI88_RS03770	735148..735516	-	369	WP_112044916.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BWI88_RS03775	735566..736210	-	645	WP_059252084.1	hypothetical protein	-
BWI88_RS03780	736225..736446	-	222	WP_000692353.1	DUF987 domain-containing protein	-
BWI88_RS03785	736515..736991	-	477	WP_001186747.1	RadC family protein	-
BWI88_RS03790	737006..737491	-	486	WP_042631074.1	antirestriction protein	-
BWI88_RS03795	737582..738400	-	819	WP_001234702.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14459.57 Da
• Isoelectric Point: 8.7427

>T72108 WP_112044915.1 NZ_CP019271:c735058-734669 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKRCNWP

Nucleotide

• Length: 390 bp

>T72108 NZ_CP019271:c735058-734669 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACGATGCAACTGGCCCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13629.35 Da
• Isoelectric Point: 6.4768

>AT72108 WP_112044916.1 NZ_CP019271:c735516-735148 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT72108 NZ_CP019271:c735516-735148 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA