Detailed information of TA system TA072095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 48290..48666
• Replicon: plasmid p13C1079T-1
• Accession: NZ_CP019268
• Organism: Escherichia coli strain 13C1079T

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: BWI87_RS24770
• Protein ID: WP_000969988.1
• Coordinates: 48484..48666 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: BWI87_RS24765
• Protein ID: WP_001324224.1
• Coordinates: 48290..48487 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI87_RS26030	43550..43786	+	237	WP_001323890.1	colicin V immunity protein	-
BWI87_RS24750	43764..44075	+	312	WP_001259758.1	colicin V	-
BWI87_RS24755	44245..46359	-	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
BWI87_RS24760	46334..47608	-	1275	WP_000489609.1	HlyD family secretion protein	-
BWI87_RS24765	48290..48487	+	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
BWI87_RS24770	48484..48666	+	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWI87_RS24775	48765..49073	+	309	WP_000377483.1	hypothetical protein	-
BWI87_RS24785	49633..50667	+	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / catA1 / tet(B) / blaTEM-1B / oqxB / oqxA / sitABCD	iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA	1..125272	125272

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T72095 WP_000969988.1 NZ_CP019268:48484-48666 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T72095 NZ_CP019268:48484-48666 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT72095 WP_001324224.1 NZ_CP019268:48290-48487 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT72095 NZ_CP019268:48290-48487 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A075MDK3