Detailed information of TA system TA072093

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4420797..4421451
• Replicon: chromosome
• Accession: NZ_CP019267
• Organism: Escherichia coli strain 13C1079T

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: F4NJ21
• Locus tag: BWI87_RS22710
• Protein ID: WP_000244772.1
• Coordinates: 4420797..4421204 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: BWI87_RS22715
• Protein ID: WP_063100142.1
• Coordinates: 4421185..4421451 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI87_RS22690	4416754..4418487	-	1734	WP_000813215.1	single-stranded-DNA-specific exonuclease RecJ	-
BWI87_RS22695	4418493..4419203	-	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
BWI87_RS22700	4419228..4420124	-	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
BWI87_RS22705	4420236..4420757	+	522	WP_001055874.1	flavodoxin FldB	-
BWI87_RS22710	4420797..4421204	-	408	WP_000244772.1	protein YgfX	Toxin
BWI87_RS22715	4421185..4421451	-	267	WP_063100142.1	FAD assembly factor SdhE	Antitoxin
BWI87_RS22720	4421694..4422674	+	981	WP_000886062.1	tRNA-modifying protein YgfZ	-
BWI87_RS22725	4422751..4423410	-	660	WP_000250274.1	hemolysin III family protein	-
BWI87_RS22730	4423574..4423885	-	312	WP_001182944.1	N(4)-acetylcytidine aminohydrolase	-
BWI87_RS22735	4423930..4425363	+	1434	WP_001363803.1	6-phospho-beta-glucosidase BglA	-
BWI87_RS22740	4425420..4426163	-	744	WP_000951964.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16048.02 Da
• Isoelectric Point: 11.2511

>T72093 WP_000244772.1 NZ_CP019267:c4421204-4420797 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T72093 NZ_CP019267:c4421204-4420797 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10548.07 Da
• Isoelectric Point: 5.1599

>AT72093 WP_063100142.1 NZ_CP019267:c4421451-4421185 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFNRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT72093 NZ_CP019267:c4421451-4421185 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTAATCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0XYB4