Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3216168..3217002 Replicon chromosome
Accession NZ_CP019259
Organism Escherichia coli strain 13C1065T

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag BWI86_RS16595 Protein ID WP_000854808.1
Coordinates 3216168..3216545 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag BWI86_RS16600 Protein ID WP_001354276.1
Coordinates 3216634..3217002 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI86_RS16555 3211175..3211666 - 492 WP_001300785.1 DUF1097 domain-containing protein -
BWI86_RS16560 3211768..3212322 - 555 WP_001001902.1 molecular chaperone YcdY -
BWI86_RS16565 3212346..3213083 - 738 WP_000283664.1 zinc-binding phosphatase -
BWI86_RS16570 3213138..3214076 - 939 WP_000351315.1 glyoxylate/hydroxypyruvate reductase GhrA -
BWI86_RS16580 3214547..3215389 - 843 WP_148116429.1 DUF4942 domain-containing protein -
BWI86_RS16585 3215474..3215671 - 198 WP_148116364.1 DUF957 domain-containing protein -
BWI86_RS16590 3215683..3216171 - 489 WP_089587850.1 hypothetical protein -
BWI86_RS16595 3216168..3216545 - 378 WP_000854808.1 type IV toxin-antitoxin system toxin CbtA Toxin
BWI86_RS16600 3216634..3217002 - 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BWI86_RS16605 3217052..3217696 - 645 WP_148116365.1 antitoxin of toxin-antitoxin stability system -
BWI86_RS16610 3217715..3217936 - 222 WP_000692353.1 DUF987 domain-containing protein -
BWI86_RS16615 3218005..3218481 - 477 WP_001186747.1 RadC family protein -
BWI86_RS16620 3218496..3218981 - 486 WP_042631074.1 antirestriction protein -
BWI86_RS16625 3219072..3219890 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 3207557..3218981 11424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T72044 WP_000854808.1 NZ_CP019259:c3216545-3216168 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T72044 NZ_CP019259:c3216545-3216168 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT72044 WP_001354276.1 NZ_CP019259:c3217002-3216634 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT72044 NZ_CP019259:c3217002-3216634 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References