Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2821724..2822362 Replicon chromosome
Accession NZ_CP019259
Organism Escherichia coli strain 13C1065T

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag BWI86_RS14390 Protein ID WP_000813794.1
Coordinates 2822186..2822362 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BWI86_RS14385 Protein ID WP_001270286.1
Coordinates 2821724..2822140 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI86_RS14365 2816876..2817817 - 942 WP_001251319.1 ABC transporter permease -
BWI86_RS14370 2817818..2818831 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
BWI86_RS14375 2818849..2819994 - 1146 WP_000047418.1 ABC transporter substrate-binding protein -
BWI86_RS14380 2820239..2821645 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
BWI86_RS14385 2821724..2822140 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
BWI86_RS14390 2822186..2822362 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
BWI86_RS14395 2822584..2822814 + 231 WP_000494244.1 YncJ family protein -
BWI86_RS14400 2822906..2824867 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
BWI86_RS14405 2824940..2825476 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
BWI86_RS14410 2825529..2826743 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T72043 WP_000813794.1 NZ_CP019259:c2822362-2822186 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T72043 NZ_CP019259:c2822362-2822186 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT72043 WP_001270286.1 NZ_CP019259:c2822140-2821724 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT72043 NZ_CP019259:c2822140-2821724 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References