Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1017161..1017959 Replicon chromosome
Accession NZ_CP019256
Organism Escherichia coli strain 13TMH22

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X1M0U2
Locus tag BWI85_RS05470 Protein ID WP_000854919.1
Coordinates 1017161..1017538 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2G4AEZ5
Locus tag BWI85_RS05475 Protein ID WP_001285608.1
Coordinates 1017585..1017959 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI85_RS05420 1012221..1012937 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
BWI85_RS05425 1012957..1014063 + 1107 WP_001044128.1 N-acetylneuraminate epimerase -
BWI85_RS05430 1014128..1015108 + 981 WP_000379695.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
BWI85_RS05435 1015116..1015238 - 123 WP_001338066.1 hypothetical protein -
BWI85_RS25840 1016228..1016374 - 147 WP_001290177.1 hypothetical protein -
BWI85_RS05460 1016459..1016656 - 198 WP_001327226.1 DUF957 domain-containing protein -
BWI85_RS05465 1016676..1017164 - 489 WP_000777664.1 hypothetical protein -
BWI85_RS05470 1017161..1017538 - 378 WP_000854919.1 TA system toxin CbtA family protein Toxin
BWI85_RS05475 1017585..1017959 - 375 WP_001285608.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BWI85_RS05480 1018039..1018260 - 222 WP_112021664.1 DUF987 domain-containing protein -
BWI85_RS05485 1018347..1018823 - 477 WP_001560293.1 RadC family protein -
BWI85_RS05490 1018838..1019317 - 480 WP_000706980.1 antirestriction protein -
BWI85_RS05495 1019583..1020401 - 819 WP_001175165.1 DUF945 domain-containing protein -
BWI85_RS05500 1020491..1020724 - 234 WP_001278293.1 DUF905 family protein -
BWI85_RS05505 1020730..1021407 - 678 WP_001097301.1 hypothetical protein -
BWI85_RS05510 1021555..1022235 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB / papC / papD 1006121..1044374 38253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.97 Da        Isoelectric Point: 7.9086

>T72009 WP_000854919.1 NZ_CP019256:c1017538-1017161 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T72009 NZ_CP019256:c1017538-1017161 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13610.37 Da        Isoelectric Point: 5.5051

>AT72009 WP_001285608.1 NZ_CP019256:c1017959-1017585 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Download         Length: 375 bp

>AT72009 NZ_CP019256:c1017959-1017585 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1M0U2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4AEZ5

References