Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 57061..57437 Replicon plasmid p13KWH46-1
Accession NZ_CP019251
Organism Escherichia coli strain 13KWH46

Toxin (Protein)


Gene name parE Uniprot ID A0A075MDK3
Locus tag BWI84_RS25670 Protein ID WP_000969988.1
Coordinates 57255..57437 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BWI84_RS25665 Protein ID WP_001324224.1
Coordinates 57061..57258 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI84_RS28915 52321..52557 + 237 WP_001323890.1 colicin V immunity protein -
BWI84_RS25650 52535..52846 + 312 WP_001259758.1 colicin V -
BWI84_RS25655 53016..55130 - 2115 WP_001183604.1 peptidase domain-containing ABC transporter -
BWI84_RS25660 55105..56379 - 1275 WP_000489609.1 HlyD family secretion protein -
BWI84_RS25665 57061..57258 + 198 WP_001324224.1 toxin-antitoxin system protein Antitoxin
BWI84_RS25670 57255..57437 + 183 WP_000969988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWI84_RS25675 57536..57844 + 309 WP_000377483.1 hypothetical protein -
BWI84_RS25685 58404..59438 + 1035 WP_001190234.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / tet(B) / catA1 / oqxB / oqxA / sitABCD iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..162357 162357


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6931.07 Da        Isoelectric Point: 4.5349

>T71991 WP_000969988.1 NZ_CP019251:57255-57437 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Download         Length: 183 bp

>T71991 NZ_CP019251:57255-57437 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7658.53 Da        Isoelectric Point: 7.2046

>AT71991 WP_001324224.1 NZ_CP019251:57061-57258 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Download         Length: 198 bp

>AT71991 NZ_CP019251:57061-57258 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075MDK3

Antitoxin

Source ID Structure

References