Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3769056..3769891 Replicon chromosome
Accession NZ_CP019243
Organism Escherichia coli strain Combat2C1

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag BWI82_RS19265 Protein ID WP_001094426.1
Coordinates 3769514..3769891 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag BWI82_RS19260 Protein ID WP_001285575.1
Coordinates 3769056..3769424 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI82_RS19225 3764949..3765629 + 681 WP_001282919.1 WYL domain-containing protein -
BWI82_RS19230 3765777..3766454 + 678 WP_001097301.1 hypothetical protein -
BWI82_RS19235 3766460..3766693 + 234 WP_001278290.1 DUF905 family protein -
BWI82_RS19240 3766783..3767601 + 819 WP_001175160.1 DUF945 domain-containing protein -
BWI82_RS19245 3767692..3768177 + 486 WP_000213697.1 antirestriction protein -
BWI82_RS19250 3768192..3768668 + 477 WP_001298074.1 RadC family protein -
BWI82_RS19255 3768755..3768976 + 222 WP_000692350.1 DUF987 domain-containing protein -
BWI82_RS19260 3769056..3769424 + 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BWI82_RS19265 3769514..3769891 + 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
BWI82_RS19270 3769888..3770376 + 489 WP_000761683.1 hypothetical protein -
BWI82_RS19275 3770388..3770585 + 198 WP_000839272.1 DUF957 domain-containing protein -
BWI82_RS27745 3770664..3770822 + 159 WP_001467148.1 hypothetical protein -
BWI82_RS19285 3771774..3773810 + 2037 WP_000417001.1 hypothetical protein -
BWI82_RS19290 3774209..3774388 - 180 WP_001298063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T71924 WP_001094426.1 NZ_CP019243:3769514-3769891 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T71924 NZ_CP019243:3769514-3769891 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT71924 WP_001285575.1 NZ_CP019243:3769056-3769424 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT71924 NZ_CP019243:3769056-3769424 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References