Detailed information of TA system TA071902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3718072..3718765
• Replicon: chromosome
• Accession: NZ_CP019240
• Organism: Rhodoferax antarcticus strain DSMZ24876

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: RA876_RS18050
• Protein ID: WP_075585380.1
• Coordinates: 3718072..3718449 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: RA876_RS18055
• Protein ID: WP_075585381.1
• Coordinates: 3718430..3718765 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RA876_RS18010	3714269..3715048	+	780	WP_075585373.1	pilus assembly protein	-
RA876_RS18015	3715416..3715736	-	321	WP_075585374.1	type II toxin-antitoxin system RelE/ParE family toxin	-
RA876_RS18020	3715736..3716014	-	279	WP_075585375.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
RA876_RS18025	3716141..3716224	+	84	Protein_3526	transposase	-
RA876_RS18030	3716354..3716617	-	264	WP_075585376.1	Txe/YoeB family addiction module toxin	-
RA876_RS18035	3716614..3716865	-	252	WP_075585377.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
RA876_RS18040	3716981..3717433	-	453	WP_075585378.1	DUF2442 domain-containing protein	-
RA876_RS18045	3717430..3717660	-	231	WP_075585379.1	DUF4160 domain-containing protein	-
RA876_RS18050	3718072..3718449	+	378	WP_075585380.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RA876_RS18055	3718430..3718765	+	336	WP_075585381.1	helix-turn-helix domain-containing protein	Antitoxin
RA876_RS18060	3718830..3719522	+	693	WP_075585382.1	transposase	-
RA876_RS18065	3719968..3721554	+	1587	WP_075585383.1	O-antigen ligase C-terminal domain-containing protein	-
RA876_RS18070	3721564..3722079	-	516	WP_075585384.1	cyclic pyranopterin monophosphate synthase MoaC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-97)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13863.14 Da
• Isoelectric Point: 10.2424

>T71902 WP_075585380.1 NZ_CP019240:3718072-3718449 [Rhodoferax antarcticus]
MTLQERPLVWIGGSKKDLMLLPTQVRKFFGHALDFAQRGDQHGAAKVLKGFGGAGVLEVVENDIGGTYRAVYTVKFEDAV
FVLHCFQKKSKSGIATPKEDMEIIRARLKVAEALAKELRNGKTHH

Nucleotide

• Length: 378 bp

>T71902 NZ_CP019240:3718072-3718449 [Rhodoferax antarcticus]
ATGACGCTACAAGAAAGACCTCTGGTCTGGATTGGGGGCAGTAAAAAAGACCTGATGCTTCTTCCAACGCAAGTGAGGAA
GTTTTTTGGTCACGCCTTGGATTTTGCGCAGCGTGGCGATCAACATGGTGCGGCAAAGGTGCTCAAGGGCTTTGGCGGTG
CTGGTGTGCTTGAGGTTGTCGAAAACGACATAGGCGGGACGTACCGCGCTGTTTACACCGTGAAATTCGAGGATGCTGTG
TTCGTCCTGCACTGCTTTCAGAAGAAGAGCAAGAGCGGCATCGCCACACCGAAGGAGGACATGGAAATCATCCGCGCTAG
GCTGAAGGTGGCTGAGGCGCTCGCAAAGGAGCTACGAAATGGAAAAACGCATCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12075.24 Da
• Isoelectric Point: 9.0415

>AT71902 WP_075585381.1 NZ_CP019240:3718430-3718765 [Rhodoferax antarcticus]
MEKRIIDGIEIETGSGNVFADLDLPDADKLKIKSGLVIEITKAVRKLGLTQDEAARRMGITQPKVSGMLRGGFANLSERK
LMDCLNRLGYDIEIKVKPAATPLGHLMLAIA

Nucleotide

• Length: 336 bp

>AT71902 NZ_CP019240:3718430-3718765 [Rhodoferax antarcticus]
ATGGAAAAACGCATCATTGACGGCATCGAGATCGAAACCGGCTCAGGCAACGTCTTCGCCGATCTTGACCTGCCCGACGC
CGACAAGCTCAAGATTAAATCCGGCTTGGTGATCGAGATCACCAAGGCCGTGCGCAAGCTCGGCCTGACCCAGGACGAAG
CAGCGCGACGCATGGGTATCACACAGCCAAAGGTGTCGGGCATGCTGCGCGGCGGCTTCGCGAACCTGTCCGAGCGCAAG
CTGATGGACTGCTTGAATCGGCTTGGCTACGACATCGAGATCAAGGTGAAGCCCGCCGCCACACCTCTCGGGCATTTGAT
GCTTGCCATTGCTTGA