Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1754874..1755553 Replicon chromosome
Accession NZ_CP019240
Organism Rhodoferax antarcticus strain DSMZ24876

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RA876_RS08505 Protein ID WP_075587048.1
Coordinates 1755128..1755553 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RA876_RS08500 Protein ID WP_075587047.1
Coordinates 1754874..1755131 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RA876_RS19875 1750381..1751229 - 849 WP_083633934.1 hypothetical protein -
RA876_RS08475 1751226..1751825 - 600 WP_075587043.1 DUF502 domain-containing protein -
RA876_RS08480 1752118..1752447 - 330 WP_139313386.1 hypothetical protein -
RA876_RS08485 1752796..1753965 + 1170 WP_075587045.1 IS4 family transposase -
RA876_RS08490 1754090..1754386 + 297 Protein_1666 type II toxin-antitoxin system RelE/ParE family toxin -
RA876_RS08495 1754388..1754690 + 303 WP_075587046.1 putative addiction module antidote protein -
RA876_RS08500 1754874..1755131 + 258 WP_075587047.1 Arc family DNA-binding protein Antitoxin
RA876_RS08505 1755128..1755553 + 426 WP_075587048.1 type II toxin-antitoxin system VapC family toxin Toxin
RA876_RS08510 1755673..1756369 + 697 Protein_1670 transposase -
RA876_RS08515 1756914..1758344 - 1431 WP_075587049.1 AAA family ATPase -
RA876_RS08520 1758501..1759676 + 1176 WP_139313387.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15298.65 Da        Isoelectric Point: 4.8723

>T71896 WP_075587048.1 NZ_CP019240:1755128-1755553 [Rhodoferax antarcticus]
MILLDTNVISEPQRQTPNARVLDWIDAQALETLYLSAITVAELRAGIALMPAGKRRDSLHENLEKRLLPMFANRVLSFDM
ACTKAYAELLAKSRVAGLAIETADAFIAAVALANGFTVATRDTSPFEAAGLNVINPWEAAQ

Download         Length: 426 bp

>T71896 NZ_CP019240:1755128-1755553 [Rhodoferax antarcticus]
ATGATCCTGCTCGATACGAACGTGATTTCGGAGCCGCAGCGCCAGACGCCTAATGCCCGCGTCCTTGACTGGATCGACGC
GCAAGCGCTGGAAACGCTCTACCTGTCCGCGATCACGGTAGCCGAGCTGCGTGCGGGTATCGCGCTGATGCCAGCCGGAA
AGCGCCGGGACAGCCTGCATGAAAACTTGGAAAAGCGCCTGCTGCCGATGTTCGCAAATCGCGTGTTGTCGTTCGATATG
GCTTGCACGAAGGCTTATGCCGAGCTGCTGGCCAAGTCCCGGGTTGCCGGCTTGGCAATTGAAACAGCTGATGCCTTCAT
TGCGGCCGTCGCCCTTGCCAACGGCTTCACCGTCGCAACCCGCGACACCAGCCCTTTTGAGGCTGCCGGGCTGAACGTCA
TCAATCCATGGGAGGCGGCGCAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9261.46 Da        Isoelectric Point: 8.9520

>AT71896 WP_075587047.1 NZ_CP019240:1754874-1755131 [Rhodoferax antarcticus]
MANVNVRNLPDEVHRAIRIQAAQHGRSTEAEIRDILGRAAKPEGRVKLGSFLASIAREAVGLTDEEHALFESGRIKSPAR
AASFE

Download         Length: 258 bp

>AT71896 NZ_CP019240:1754874-1755131 [Rhodoferax antarcticus]
ATGGCAAACGTGAATGTAAGAAATCTGCCCGACGAAGTGCATCGGGCCATCCGAATCCAAGCCGCCCAGCACGGCCGCAG
CACCGAGGCTGAAATCCGCGACATTTTGGGGCGGGCTGCGAAGCCCGAGGGTCGCGTGAAACTTGGCTCTTTCTTGGCAT
CTATCGCCCGCGAGGCTGTCGGCCTGACCGATGAAGAACACGCCCTGTTTGAAAGCGGGCGTATCAAGTCCCCGGCCCGT
GCGGCGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References