Detailed information of TA system TA071892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 466591..467171
• Replicon: chromosome
• Accession: NZ_CP019240
• Organism: Rhodoferax antarcticus strain DSMZ24876

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: RA876_RS02240
• Protein ID: WP_076072005.1
• Coordinates: 466917..467171 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: RA876_RS02235
• Protein ID: WP_076072002.1
• Coordinates: 466591..466920 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RA876_RS02195	461908..462354	+	447	WP_076071987.1	maturase	-
RA876_RS02200	462415..462726	-	312	WP_076071989.1	helix-turn-helix transcriptional regulator	-
RA876_RS02205	462713..463045	-	333	WP_076071992.1	type II toxin-antitoxin system RelE/ParE family toxin	-
RA876_RS02210	463197..463829	-	633	WP_076071994.1	hypothetical protein	-
RA876_RS20160	464263..464460	+	198	WP_156876189.1	hypothetical protein	-
RA876_RS02220	464525..465744	+	1220	Protein_441	group II intron reverse transcriptase/maturase	-
RA876_RS02225	465838..466137	-	300	WP_076071997.1	HigA family addiction module antidote protein	-
RA876_RS02230	466150..466431	-	282	WP_076072000.1	type II toxin-antitoxin system RelE/ParE family toxin	-
RA876_RS02235	466591..466920	-	330	WP_076072002.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RA876_RS02240	466917..467171	-	255	WP_076072005.1	type II toxin-antitoxin system HicA family toxin	Toxin
RA876_RS02245	467248..467490	-	243	WP_083639662.1	hypothetical protein	-
RA876_RS02250	467483..467758	-	276	WP_076072009.1	BrnT family toxin	-
RA876_RS02255	467789..468049	-	261	WP_076072011.1	hypothetical protein	-
RA876_RS02260	468036..468308	-	273	WP_076072014.1	BrnT family toxin	-
RA876_RS02265	468386..468916	-	531	WP_076072017.1	hypothetical protein	-
RA876_RS02270	468913..469290	-	378	WP_076072019.1	hypothetical protein	-
RA876_RS20165	469400..469720	-	321	WP_156876190.1	hypothetical protein	-
RA876_RS02275	470087..470941	+	855	WP_156876191.1	integron integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	460025..461740	1715

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9632.94 Da
• Isoelectric Point: 10.4421

>T71892 WP_076072005.1 NZ_CP019240:c467171-466917 [Rhodoferax antarcticus]
MKRRHQRIVELIFSRPTSGNVQWRDVEGLFAELGAEIEERAGSRVSVFLFGEVRVFHRPHPSPNTDKGAVASIRKWLEQH
GVEP

Nucleotide

• Length: 255 bp

>T71892 NZ_CP019240:c467171-466917 [Rhodoferax antarcticus]
ATGAAACGCAGGCATCAGCGAATTGTTGAATTGATTTTTTCGCGGCCAACAAGCGGCAACGTCCAGTGGCGCGATGTTGA
GGGCCTTTTCGCTGAACTGGGGGCTGAGATTGAAGAGCGGGCGGGCAGTCGCGTTTCTGTCTTTTTGTTTGGCGAAGTGC
GGGTTTTTCACCGTCCGCATCCATCACCAAACACAGACAAAGGCGCGGTGGCATCTATCCGCAAATGGCTGGAACAACAC
GGAGTCGAACCATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12165.81 Da
• Isoelectric Point: 6.0799

>AT71892 WP_076072002.1 NZ_CP019240:c466920-466591 [Rhodoferax antarcticus]
MNVMTVDDYHATIEFDPDLDMFRGEILGLNGGADFYGKNPKELRAEFKHSLDVFLEACGEKGIEPKRHFSGKFNLRISPQ
LHEKLAIAAQARGKSINALAQQALQESFA

Nucleotide

• Length: 330 bp

>AT71892 NZ_CP019240:c466920-466591 [Rhodoferax antarcticus]
ATGAACGTAATGACTGTTGACGACTATCACGCAACGATTGAATTTGATCCTGATCTTGACATGTTCCGGGGCGAAATTCT
CGGCCTGAACGGTGGCGCAGATTTCTACGGTAAGAATCCGAAGGAGCTCCGTGCGGAGTTCAAGCATTCGCTTGATGTTT
TTCTTGAAGCGTGTGGCGAGAAGGGCATTGAACCCAAACGACACTTTTCTGGGAAATTTAACCTGCGGATTTCCCCGCAA
TTGCACGAAAAACTCGCAATTGCGGCGCAAGCAAGAGGTAAAAGTATCAATGCGTTGGCGCAACAGGCTTTGCAGGAAAG
CTTTGCGTGA