Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 30732..31426 Replicon chromosome
Accession NZ_CP019240
Organism Rhodoferax antarcticus strain DSMZ24876

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RA876_RS00155 Protein ID WP_075585563.1
Coordinates 30998..31426 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RA876_RS00150 Protein ID WP_075585562.1
Coordinates 30732..30998 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RA876_RS00130 26141..26515 + 375 WP_075585617.1 hypothetical protein -
RA876_RS00135 26590..27549 - 960 WP_075585559.1 LysR family transcriptional regulator -
RA876_RS00140 27641..28990 + 1350 WP_075585560.1 aspartate aminotransferase family protein -
RA876_RS00145 29069..30574 + 1506 WP_075585561.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
RA876_RS00150 30732..30998 + 267 WP_075585562.1 hypothetical protein Antitoxin
RA876_RS00155 30998..31426 + 429 WP_075585563.1 VapC toxin family PIN domain ribonuclease Toxin
RA876_RS00160 31653..32390 + 738 WP_075585564.1 ABC transporter ATP-binding protein -
RA876_RS00165 32387..33157 + 771 WP_075585620.1 outer membrane lipoprotein-sorting protein -
RA876_RS00170 33162..34439 + 1278 WP_076071964.1 hypothetical protein -
RA876_RS00175 34452..35849 + 1398 WP_075585618.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-138)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15641.84 Da        Isoelectric Point: 6.8811

>T71889 WP_075585563.1 NZ_CP019240:30998-31426 [Rhodoferax antarcticus]
MRALLDINVLIALHDQDHVHHTRAADWLDAHSAQGWASSPLTQNGCLRIMSQSAYSNPQPLSVLVQMLQNSTATAWHALW
SDDLSLLDASAFVHARIHSPKQLTDVYLLGLAVKHQGCLVSFDQRIPLSAVHGAKPDHFVVL

Download         Length: 429 bp

>T71889 NZ_CP019240:30998-31426 [Rhodoferax antarcticus]
ATGCGCGCGCTGCTCGATATCAACGTGCTGATTGCCCTGCACGACCAGGACCATGTGCACCACACGCGGGCGGCCGACTG
GCTTGACGCGCACAGTGCGCAGGGCTGGGCCAGCAGCCCGCTGACGCAAAACGGCTGTTTGCGCATCATGAGCCAAAGCG
CTTACAGCAACCCTCAGCCCTTGTCAGTGCTGGTTCAGATGCTGCAAAATTCGACAGCCACGGCCTGGCATGCGCTGTGG
AGCGATGACCTCAGCCTTCTCGATGCAAGCGCATTTGTTCATGCACGCATCCACAGCCCCAAACAGCTAACCGATGTGTA
TTTGCTGGGCCTGGCAGTCAAGCATCAAGGCTGCCTGGTCAGCTTCGACCAGCGCATCCCGTTGAGCGCCGTTCACGGGG
CCAAACCAGACCACTTTGTGGTTTTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9410.72 Da        Isoelectric Point: 8.6599

>AT71889 WP_075585562.1 NZ_CP019240:30732-30998 [Rhodoferax antarcticus]
MRTTLDIADDILFAAKELAQREKKSLGQVISELARRAFAAPAGSNPVNPNAPLQAAEGLATYGIRPLPKRGGVVSNEQID
RLRDAEGI

Download         Length: 267 bp

>AT71889 NZ_CP019240:30732-30998 [Rhodoferax antarcticus]
ATGCGCACAACCCTGGACATTGCCGACGACATCTTGTTTGCCGCCAAAGAATTGGCGCAGCGTGAGAAAAAATCGCTCGG
CCAGGTGATCAGCGAACTGGCCAGGCGCGCATTTGCCGCCCCTGCCGGGTCAAATCCCGTTAACCCGAATGCGCCACTGC
AGGCCGCCGAAGGCTTGGCCACCTATGGCATTCGTCCTTTGCCCAAGCGCGGCGGCGTGGTCAGCAACGAACAAATTGAC
CGACTGCGTGATGCTGAGGGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References