Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 32505..33046 Replicon plasmid pDHQP20152271_1
Accession NZ_CP019224
Organism Mycobacterium intracellulare subsp. chimaera strain CDC 2015-22-71 isolate PA-Patient

Toxin (Protein)


Gene name parE Uniprot ID D5P595
Locus tag BWK49_RS28890 Protein ID WP_007172365.1
Coordinates 32753..33046 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A854I1S2
Locus tag BWK49_RS28885 Protein ID WP_040624378.1
Coordinates 32505..32756 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWK49_RS28865 28017..29879 - 1863 WP_023363516.1 helicase associated domain-containing protein -
BWK49_RS28870 30256..30540 - 285 WP_007172369.1 hypothetical protein -
BWK49_RS29705 30503..31093 - 591 WP_023363514.1 hypothetical protein -
BWK49_RS28875 31149..31586 - 438 WP_007172368.1 WhiB family transcriptional regulator -
BWK49_RS28880 31893..32399 + 507 WP_007172367.1 helix-turn-helix domain-containing protein -
BWK49_RS28885 32505..32756 + 252 WP_040624378.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BWK49_RS28890 32753..33046 + 294 WP_007172365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWK49_RS28895 33264..33971 + 708 WP_139315443.1 hypothetical protein -
BWK49_RS28900 33985..34683 + 699 WP_139315442.1 hypothetical protein -
BWK49_RS28905 34798..35877 + 1080 WP_007172361.1 hypothetical protein -
BWK49_RS29710 35987..36658 + 672 WP_139315441.1 hypothetical protein -
BWK49_RS29715 36782..37054 + 273 WP_139315440.1 hypothetical protein -
BWK49_RS29720 37285..37716 + 432 WP_139315439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..97268 97268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.74 Da        Isoelectric Point: 6.9772

>T71866 WP_007172365.1 NZ_CP019224:32753-33046 [Mycobacterium intracellulare subsp. chimaera]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL

Download         Length: 294 bp

>T71866 NZ_CP019224:32753-33046 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCGCATACGTCCTTTCACCCGCTGCGCAAGCAGATTTGGAACAGATCTGGGACTACACGCACGAGCACTGGGGCCT
GGATCAGGCTGAGCAGTACCTGCGAGAACTTCAACGCGCTATCGAGCGCGCAGCGGCGAACCCCCGGATCGGGCGGGCCT
GCGACGAGATCCGCCCGGGCTATCGCAAGCTGGCAGCCGGGTCGCACATGCTGTTTTATCGGGTGACAACCCAAGGCTTC
CTCGATGTCGTGCGTGTCCTGCACCAACGCATGGACGTCGACCGCCACCTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9203.22 Da        Isoelectric Point: 5.8579

>AT71866 WP_040624378.1 NZ_CP019224:32505-32756 [Mycobacterium intracellulare subsp. chimaera]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR

Download         Length: 252 bp

>AT71866 NZ_CP019224:32505-32756 [Mycobacterium intracellulare subsp. chimaera]
GTGGGTAAAAACACGTCCTTCAGTCTCGATGAGCATTACAGCGCCTTCATTGAGGCTGAGGTGGCTGCGGGACGTTACCG
GTCGGCCAGTGATGTCGTGCGCTCCGCGTTGCGGTTACTCGAGGACCGTGAAATTCAGCTTCGGGCACTGCGCGAGGCGC
TAGTGGCCGGTGAGCGCAGCGGCACTTCAACACCGTTTGACTTCGACGCCTTCCTCGACGGCAAACGCGCCGAAAAGCCG
CAAGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0TBP0

Antitoxin

Source ID Structure
AlphaFold DB A0A854I1S2

References