Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 2025803..2026302 Replicon chromosome
Accession NZ_CP019221
Organism Mycobacterium intracellulare subsp. chimaera strain CDC 2015-22-71 isolate PA-Patient

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1Y0T0F0
Locus tag BWK49_RS09805 Protein ID WP_042911194.1
Coordinates 2025803..2026060 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1Y0T5M8
Locus tag BWK49_RS09810 Protein ID WP_042911195.1
Coordinates 2026057..2026302 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWK49_RS09795 2021348..2023702 + 2355 WP_042911192.1 glycerol-3-phosphate 1-O-acyltransferase -
BWK49_RS09800 2023731..2025806 + 2076 WP_042911193.1 cytochrome c oxidase assembly protein -
BWK49_RS09805 2025803..2026060 - 258 WP_042911194.1 Txe/YoeB family addiction module toxin Toxin
BWK49_RS09810 2026057..2026302 - 246 WP_042911195.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BWK49_RS09815 2026510..2026980 + 471 WP_008255143.1 single-stranded DNA-binding protein -
BWK49_RS09820 2027058..2028734 + 1677 WP_009955480.1 energy-dependent translational throttle protein EttA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9873.43 Da        Isoelectric Point: 9.9087

>T71860 WP_042911194.1 NZ_CP019221:c2026060-2025803 [Mycobacterium intracellulare subsp. chimaera]
MNIVFAPQAWDDYLHWQTADRAVLKRINKLIAEACRSPQAGIGKPEPLKYGLVGAWSRRITQEHRLVYRVVGDDLQILQA
RFHYI

Download         Length: 258 bp

>T71860 NZ_CP019221:c2026060-2025803 [Mycobacterium intracellulare subsp. chimaera]
ATGAACATCGTCTTCGCGCCTCAAGCGTGGGACGACTACCTGCACTGGCAGACGGCCGACCGGGCCGTGCTCAAGCGGAT
CAACAAGCTCATCGCGGAGGCTTGCCGGTCGCCGCAGGCGGGCATCGGCAAGCCTGAGCCCCTGAAATACGGGCTCGTCG
GCGCCTGGTCCCGGCGAATTACCCAGGAACACCGGCTCGTCTATCGGGTCGTCGGCGATGACCTGCAGATCCTCCAGGCC
CGGTTTCACTACATCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8947.01 Da        Isoelectric Point: 4.5742

>AT71860 WP_042911195.1 NZ_CP019221:c2026302-2026057 [Mycobacterium intracellulare subsp. chimaera]
VAITASEARKNLFPLIEKVNADRTSIEITSKAGRAVLMSADDWEAWQETAYLFQSPANARRLLDAADALDRGRGIRADLD
E

Download         Length: 246 bp

>AT71860 NZ_CP019221:c2026302-2026057 [Mycobacterium intracellulare subsp. chimaera]
GTGGCCATCACGGCGAGCGAGGCGCGCAAGAACCTGTTTCCCCTGATCGAGAAGGTGAACGCCGACCGGACGTCGATCGA
GATCACGTCGAAAGCTGGTCGCGCGGTGCTGATGTCCGCCGATGACTGGGAGGCGTGGCAGGAGACGGCATACCTGTTCC
AGTCCCCGGCGAACGCCCGCCGGCTCCTCGACGCCGCTGACGCCCTGGACAGGGGCCGCGGAATCCGGGCCGACCTCGAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0T0F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y0T5M8

References