Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1603657..1604219 Replicon chromosome
Accession NZ_CP019221
Organism Mycobacterium intracellulare subsp. chimaera strain CDC 2015-22-71 isolate PA-Patient

Toxin (Protein)


Gene name vapC Uniprot ID A0A081I0A5
Locus tag BWK49_RS07925 Protein ID WP_036454801.1
Coordinates 1603851..1604219 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A081I0A4
Locus tag BWK49_RS07920 Protein ID WP_036455532.1
Coordinates 1603657..1603854 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWK49_RS07885 1598761..1599906 - 1146 WP_179945068.1 hypothetical protein -
BWK49_RS07890 1600036..1601109 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
BWK49_RS07895 1601126..1601866 + 741 WP_042910933.1 aminoglycoside 3'-phosphotransferase -
BWK49_RS07900 1601954..1602238 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BWK49_RS07905 1602253..1602498 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin -
BWK49_RS07910 1602534..1603085 + 552 WP_036454798.1 VOC family protein -
BWK49_RS07915 1603164..1603562 + 399 WP_036454800.1 VOC family protein -
BWK49_RS07920 1603657..1603854 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BWK49_RS07925 1603851..1604219 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin Toxin
BWK49_RS07930 1604402..1604743 + 342 WP_172417493.1 hypothetical protein -
BWK49_RS29835 1604829..1605188 + 360 WP_042910935.1 hypothetical protein -
BWK49_RS07940 1605373..1605948 + 576 WP_075630262.1 C40 family peptidase -
BWK49_RS07945 1606311..1606634 + 324 WP_036454806.1 antibiotic biosynthesis monooxygenase -
BWK49_RS07950 1606672..1607505 - 834 WP_036454808.1 SAM-dependent methyltransferase -
BWK49_RS07955 1607540..1608223 - 684 WP_036455537.1 hypothetical protein -
BWK49_RS07960 1608370..1608579 + 210 WP_072501223.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13435.74 Da        Isoelectric Point: 6.4862

>T71859 WP_036454801.1 NZ_CP019221:1603851-1604219 [Mycobacterium intracellulare subsp. chimaera]
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA

Download         Length: 369 bp

>T71859 NZ_CP019221:1603851-1604219 [Mycobacterium intracellulare subsp. chimaera]
ATGATCCTCGTCGACACCGCGGTGTGGATCGATCATCTACACACCGCGGAGTTGCGGCTAGTCAAGCTGCTGGAGATCGA
CCAAGTTGGCTGTCATGCGCTGGTCATCGAAGAGCTGGCGCTGGGGTCGATCTCGCGACGTGAGGTGGTGCTCGACCTCC
TCGCGAATCTTCGCCAGTTTCCGACCGTCCAGCACGCCGAGATCCTTCACCTCACCGGTCAACGCAAACTGTATGGACGC
GGTCTCAGTGCGGTCGACGTCCATCTCATGGCCGCCGTCGCCCTGGTTGAAGGCGCGCAGCTGTGGACGAGAGACAAGCG
GTTGAAGGCTGCGTCGGTCGATGCGGGCATCGCACTCTTCGATGCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6871.88 Da        Isoelectric Point: 11.6072

>AT71859 WP_036455532.1 NZ_CP019221:1603657-1603854 [Mycobacterium intracellulare subsp. chimaera]
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG

Download         Length: 198 bp

>AT71859 NZ_CP019221:1603657-1603854 [Mycobacterium intracellulare subsp. chimaera]
ATGCGGACCACAGTCACGATCGACGACGACCTGTTGGCCAAGGCTGCTGAGTTGACCGGCGTGCGCGAGAACGTCGCGTT
GCTCCGCGAGGGATTGCAGACGCTGATCAGGGTGGAAAGCGCTCGCCGACTTGCCGCGCTCGGCGGGACGGATGCCGGGG
CGGTGGCCGCTCCCCGGCGCCGCCGTGGGACTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081I0A5

Antitoxin

Source ID Structure
AlphaFold DB A0A081I0A4

References