Detailed information of TA system TA071850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4631732..4632248
• Replicon: chromosome
• Accession: NZ_CP019219
• Organism: Klebsiella pneumoniae strain 1756

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BWG70_RS23705
• Protein ID: WP_076027657.1
• Coordinates: 4631732..4632016 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: BWG70_RS23710
• Protein ID: WP_002886901.1
• Coordinates: 4632006..4632248 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWG70_RS23675	4627215..4627523	-	309	WP_004894688.1	PTS sugar transporter subunit IIB	-
BWG70_RS28575	4627608..4627781	+	174	WP_032408826.1	hypothetical protein	-
BWG70_RS23685	4627784..4628527	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
BWG70_RS23695	4628884..4631022	+	2139	WP_076027656.1	anaerobic ribonucleoside-triphosphate reductase	-
BWG70_RS23700	4631264..4631728	+	465	WP_048968808.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
BWG70_RS23705	4631732..4632016	-	285	WP_076027657.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWG70_RS23710	4632006..4632248	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BWG70_RS23715	4632326..4634236	-	1911	WP_076027658.1	BglG family transcription antiterminator	-
BWG70_RS23720	4634259..4635413	-	1155	WP_023159544.1	lactonase family protein	-
BWG70_RS23725	4635480..4636220	-	741	WP_076027659.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11115.96 Da
• Isoelectric Point: 10.4610

>T71850 WP_076027657.1 NZ_CP019219:c4632016-4631732 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKGSGYRLVHQLRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T71850 NZ_CP019219:c4632016-4631732 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATTTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGGGTCAGGTTATCGGTTGGTGCATCAACTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT71850 WP_002886901.1 NZ_CP019219:c4632248-4632006 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT71850 NZ_CP019219:c4632248-4632006 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0