Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 87628..88147 Replicon plasmid p41-1
Accession NZ_CP019209
Organism Enterococcus faecium strain 2014-VREF-41

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag BVA20_RS15840 Protein ID WP_000588503.1
Coordinates 87890..88147 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag BVA20_RS15835 Protein ID WP_000388479.1
Coordinates 87628..87897 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVA20_RS15780 82825..83724 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
BVA20_RS15785 83727..84212 + 486 WP_002303313.1 single-stranded DNA-binding protein -
BVA20_RS15790 84353..84556 - 204 WP_002316074.1 putative holin-like toxin -
BVA20_RS15795 84631..84891 + 261 WP_002295623.1 hypothetical protein -
BVA20_RS15805 85328..85534 + 207 WP_002347218.1 hypothetical protein -
BVA20_RS15810 85534..85785 + 252 WP_002296238.1 hypothetical protein -
BVA20_RS15815 85800..86237 + 438 WP_002300851.1 hypothetical protein -
BVA20_RS15820 86230..86937 + 708 WP_002303117.1 hypothetical protein -
BVA20_RS15830 87318..87497 + 180 WP_001120991.1 hypothetical protein -
BVA20_RS15835 87628..87897 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BVA20_RS15840 87890..88147 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
BVA20_RS17220 88606..88761 + 156 WP_002347142.1 hypothetical protein -
BVA20_RS15845 88785..89609 + 825 WP_001809248.1 hypothetical protein -
BVA20_RS15850 89774..90388 - 615 WP_001261742.1 recombinase family protein -
BVA20_RS15855 90626..91048 + 423 WP_002303116.1 hypothetical protein -
BVA20_RS15860 91058..91261 + 204 WP_002299573.1 hypothetical protein -
BVA20_RS15865 91472..92056 + 585 WP_002299575.1 recombinase family protein -
BVA20_RS15870 92245..92925 - 681 WP_010861579.1 IS6-like element IS1216 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..215998 215998


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-85)

Antitoxin

(1-72)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T71831 WP_000588503.1 NZ_CP019209:87890-88147 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T71831 NZ_CP019209:87890-88147 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT71831 WP_000388479.1 NZ_CP019209:87628-87897 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT71831 NZ_CP019209:87628-87897 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8


Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References