Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 87628..88147 | Replicon | plasmid p41-1 |
Accession | NZ_CP019209 | ||
Organism | Enterococcus faecium strain 2014-VREF-41 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | BVA20_RS15840 | Protein ID | WP_000588503.1 |
Coordinates | 87890..88147 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | BVA20_RS15835 | Protein ID | WP_000388479.1 |
Coordinates | 87628..87897 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BVA20_RS15780 | 82825..83724 | + | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
BVA20_RS15785 | 83727..84212 | + | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
BVA20_RS15790 | 84353..84556 | - | 204 | WP_002316074.1 | putative holin-like toxin | - |
BVA20_RS15795 | 84631..84891 | + | 261 | WP_002295623.1 | hypothetical protein | - |
BVA20_RS15805 | 85328..85534 | + | 207 | WP_002347218.1 | hypothetical protein | - |
BVA20_RS15810 | 85534..85785 | + | 252 | WP_002296238.1 | hypothetical protein | - |
BVA20_RS15815 | 85800..86237 | + | 438 | WP_002300851.1 | hypothetical protein | - |
BVA20_RS15820 | 86230..86937 | + | 708 | WP_002303117.1 | hypothetical protein | - |
BVA20_RS15830 | 87318..87497 | + | 180 | WP_001120991.1 | hypothetical protein | - |
BVA20_RS15835 | 87628..87897 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
BVA20_RS15840 | 87890..88147 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
BVA20_RS17220 | 88606..88761 | + | 156 | WP_002347142.1 | hypothetical protein | - |
BVA20_RS15845 | 88785..89609 | + | 825 | WP_001809248.1 | hypothetical protein | - |
BVA20_RS15850 | 89774..90388 | - | 615 | WP_001261742.1 | recombinase family protein | - |
BVA20_RS15855 | 90626..91048 | + | 423 | WP_002303116.1 | hypothetical protein | - |
BVA20_RS15860 | 91058..91261 | + | 204 | WP_002299573.1 | hypothetical protein | - |
BVA20_RS15865 | 91472..92056 | + | 585 | WP_002299575.1 | recombinase family protein | - |
BVA20_RS15870 | 92245..92925 | - | 681 | WP_010861579.1 | IS6-like element IS1216 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..215998 | 215998 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T71831 WP_000588503.1 NZ_CP019209:87890-88147 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T71831 NZ_CP019209:87890-88147 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT71831 WP_000388479.1 NZ_CP019209:87628-87897 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT71831 NZ_CP019209:87628-87897 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |